2-dehydropantoate 2-reductase

In enzymology, a 2-dehydropantoate 2-reductase (EC number|1.1.1.169) is an enzyme that catalyzes the chemical reaction

:(R)-pantoate + NADP⁺ $ightleftharpoons$ 2-dehydropantoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantoate and NADP⁺, whereas its 3 products are 2-dehydropantoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1KS9, PDB link|1YJQ, PDB link|1YON, PDB link|2EW2, and PDB link|2OFP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37211-74-8."

Gene Ontology (GO) codes