20alpha-hydroxysteroid dehydrogenase

In enzymology, a 20alpha-hydroxysteroid dehydrogenase (EC number|1.1.1.149) is an enzyme that catalyzes the chemical reaction

:17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ $ightleftharpoons$ 17alpha-hydroxyprogesterone + NAD(P)H + H⁺

The 3 substrates of this enzyme are 17alpha,20alpha-dihydroxypregn-4-en-3-one, NAD⁺, and NADP⁺, whereas its 4 products are 17-alpha-hydroxyprogesterone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase. Other names in common use include 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxy steroid dehydrogenase, 20alpha-HSD, and 20alpha-HSDH. This enzyme participates in c21-steroid hormone metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1MRQ, PDB link|1Q13, and PDB link|1Q5M.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9040-08-8."

Gene Ontology (GO) codes