Mevaldate reductase

Mevaldate reductase
mevaldate reductase (NAD+)
Identifiers
EC number 1.1.1.32
CAS number 9028-33-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NAD+ \rightleftharpoons mevaldate + NADH + H+

Thus, the two substrates of this enzyme are (R)-mevalonate and NAD+, whereas its 3 products are mevaldate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.

References

  • Schlesinger MJ and Coon MJ (1961). "Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver". J. Biol. Chem. 236: 2421–2424. 

External links

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