L-iditol 2-dehydrogenase

In enzymology, a L-iditol 2-dehydrogenase (EC number|1.1.1.14) is an enzyme that catalyzes the chemical reaction

:L-iditol + NAD⁺ $ightleftharpoons$ L-sorbose + NADH + H⁺

Thus, the two substrates of this enzyme are L-iditol and NAD⁺, whereas its 3 products are L-sorbose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-iditol:NAD+ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD+ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD+ oxidoreductase, NAD+-dependent sorbitol dehydrogenase, NAD+-dependent sorbitol dehydrogenase, and NAD+-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1K2W, PDB link|1PL6, PDB link|1PL7, and PDB link|1PL8.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-21-1."

Gene Ontology (GO) codes