D-threo-aldose 1-dehydrogenase

D-threo-aldose 1-dehydrogenase
D-threo-aldose 1-dehydrogenase
Identifiers
EC number 1.1.1.122
CAS number 9082-70-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) is an enzyme that catalyzes the chemical reaction

a D-threo-aldose + NAD+ \rightleftharpoons a D-threo-aldono-1,5-lactone + NADH + H+

Thus, the two substrates of this enzyme are D-threo-aldose and NAD+, whereas its 3 products are D-threo-aldono-1,5-lactone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-threo-aldose:NAD+ 1-oxidoreductase. Other names in common use include L-fucose dehydrogenase, (2S,3R)-aldose dehydrogenase, dehydrogenase, L-fucose, and L-fucose (D-arabinose) dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

References

  • Sasajima KI, Sinskey AJ (1979). "Oxidation of L-glucose by a Pseudomonad". Biochim. Biophys. Acta. 571 (1): 120–6. PMID 40609. 
  • Schachter H, Sarney J, McGuire EJ, Roseman S (1969). "Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver". J. Biol. Chem. 244 (17): 4785–92. PMID 4309152. 
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