DTDP-6-deoxy-L-talose 4-dehydrogenase

DTDP-6-deoxy-L-talose 4-dehydrogenase
dTDP-6-deoxy-L-talose 4-dehydrogenase
Identifiers
EC number 1.1.1.134
CAS number 37250-65-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dTDP-6-deoxy-L-talose 4-dehydrogenase (EC 1.1.1.134) is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-talose + NADP+ \rightleftharpoons dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+

Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-talose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase. Other names in common use include thymidine diphospho-6-deoxy-L-talose dehydrogenase, TDP-6-deoxy-L-talose dehydrogenase, thymidine diphospho-6-deoxy-L-talose dehydrogenase, and dTDP-6-deoxy-L-talose dehydrogenase (4-reductase). This enzyme participates in nucleotide sugars metabolism.

References

  • Gaugler RW, Gabriel O (1973). "Biological mechanisms involved in the formation of deoxy sugars VII. Biosynthesis of 6-deoxy-L-talose". J. Biol. Chem. 248 (17): 6041–9. PMID 4199258.