Dihydrobunolol dehydrogenase

Dihydrobunolol dehydrogenase
dihydrobunolol dehydrogenase
Identifiers
EC number 1.1.1.160
CAS number 62213-61-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dihydrobunolol dehydrogenase (EC 1.1.1.160) is an enzyme that catalyzes the chemical reaction

(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1- naphthol + NADP+ \rightleftharpoons (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)- naphthalenone + NADPH + H+

The three substrates of this enzyme are [[(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-]], naphthol, and NADP+, whereas its 4 products are [[(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-]], naphthalenone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-n aphthol:NADP+ oxidoreductase. This enzyme is also termed bunolol reductase.

References

  • Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2 (2): 191–202. doi:10.3109/00498257209111050. PMID 4560367. 
  • Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2 (2): 191–202. doi:10.3109/00498257209111050. PMID 4560367. 
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