D-arabinitol 4-dehydrogenase

D-arabinitol 4-dehydrogenase
Identifiers
EC number	1.1.1.11
CAS number	9028-18-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a D-arabinitol 4-dehydrogenase (EC 1.1.1.11) is an enzyme that catalyzes the chemical reaction

D-arabinitol + NAD⁺ $\rightleftharpoons$ D-xylulose + NADH + H⁺

Thus, the two substrates of this enzyme are D-arabinitol and NAD⁺, whereas its 3 products are D-xylulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-arabinitol:NAD+ 4-oxidoreductase. Other names in common use include D-arabitol dehydrogenase, and arabitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

References

• Lin ECC (1961). "An inducible D-arabitol dehydrogenase from Aerobacter aerogenes". J. Biol. Chem. 236: 31–36. PMID 13762204. 
• Wood WA, McDonough MJ and Jacobs LB (1961). "Ribitol and D-arabitol utilization by Aerobacter aerogenes". J. Biol. Chem. 236: 2190–2195. 

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