Aldose-6-phosphate reductase (NADPH)
- Aldose-6-phosphate reductase (NADPH)
In enzymology, an aldose-6-phosphate reductase (NADPH) (EC number|1.1.1.200) is an enzyme that catalyzes the chemical reaction
:D-sorbitol 6-phosphate + NADP+ D-glucose 6-phosphate + NADPH + H+
Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NADP+, whereas its 3 products are D-glucose 6-phosphate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP+ 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP+-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP+ 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).
References
*
External links
::"The CAS registry number for this enzyme class is CAS registry|76901-04-7."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
Aldose reductase — (or aldehyde reductase) is an enzyme in carbohydrate metabolism that converts an aldose to a sugar alcohol, using NADPH as the reducing agent.The enzyme can be inhibited by aldose reductase inhibitors.ReactionsSpecific reactions catalyzed by this … Wikipedia
aldose — A monosaccharide potentially containing the characteristic group of the aldehydes, CHO; a polyhydroxyaldehyde. a. mutarotase SYN: a. 1 epimerase. a. reductase polyol dehydrogenase (NADP+); an oxidoreductase that reversibly converts aldoses to… … Medical dictionary
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia
Oxidoreductase — In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). This… … Wikipedia
AKR1B1 — Aldo keto reductase family 1, member B1 (aldose reductase), also known as AKR1B1, is a human gene. PBB Summary section title = summary text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known… … Wikipedia
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
Galactosemic cataract — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICD9|366.44, ICD9|271.1 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = A Galactosemic cataract is cataract which is associated with the consequences of… … Wikipedia
Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… … Wikipedia
Nicotinamide adenine dinucleotide — Nicotinamide adenine dinucleotide … Wikipedia
Polyol pathway — Also called the sorbitol aldose reductase pathway, the polyol pathway appears to be implicated in diabetic complications, especially in microvascular damage to the retina, kidney and nerves. The Pathway Cells use glucose for energy, though unused … Wikipedia
