Xanthine dehydrogenase

In enzymology, a xanthine dehydrogenase (EC number|1.17.1.4) is an enzyme that catalyzes the chemical reaction

:xanthine + NAD⁺ + H₂O $ightleftharpoons$ urate + NADH + H⁺

The 3 substrates of this enzyme are xanthine, NAD⁺, and H₂O, whereas its 3 products are urate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is xanthine:NAD+ oxidoreductase. Other names in common use include NAD+-xanthine dehydrogenase, xanthine-NAD+ oxidoreductase, xanthine/NAD+ oxidoreductase, and xanthine oxidoreductase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2E1Q and PDB link|2E3T.

References

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External links

Gene Ontology (GO) codes