HLA-A23

monoisoform
isoformgroup = HLA-A23
polymer_type = MHC Class I, A cell surface antigen

---

protein_type = transmembrane receptor/ligand
structure = αβ heterodimer
subunit_genes = HLA-A*2301, β₂-microglobulin
linkout = HAwA
alias = HL-A9
isoformCount = 1
subunit1 = allele
nick1 = A23
allele1a = 2301

HLA-A23 (A23) is a human leukocyte antigen "serotype" within HLA-A serotype group. The serotype is determined by the antibody recognition of α²³ subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A*23 allele group and the β-chain are encoded by B2M .cite journal |author=Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF |title=The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin |journal=Tissue Antigens |volume=11 |issue=2 |pages=96–112 |year=1978 |month=February |pmid=77067 |doi= |url=] This group currently is dominated by A*2301. A23 and A*23 are almost synonymous in meaning.A23 is a of the HLA-A9 and it is a sister serotype of HLA-A24.

A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.

erotype

Serotype
color1=#B0E0FF |color2=#E0F0FF | color3 = #F0F8FF
gene = A
type = 23
types = 2
allelegroup = 23
alleles = 1
2ndType = 24
type2alle1freq = 1
allele1 = 01 |type1alle1freq = 95 |N1 = 5119

Allele

AlleleFreq
Placement = right
Allele = A*2301
Freq1 = 22.8 | People1 = Mali Bandiagara
Freq2 = 18.7 | People2 = Cameroon Yaounde
Freq3 = 17.7 | People3 = Senegal Niokholo Mandenka
Freq4 = 15.6 | People4 = Guinea Bissau
Freq5 = 14.9 | People5 = Cameroon Bamileke
Freq6 = 14.8 | People6 = Cape Verde Southeastern I…
Freq7 = 13.5 | People7 = Cameroon Beti
Freq8 = 12.7 | People8 = Zimbabwe Harare Shona
Freq9 = 11.1 | People9 = USA African America
Freq10 = 10.9 | People10 = Portugal North
Freq11 = 10.0 | People11 = South Africian Natal Zulu
Freq12 = 9.5 | People12 = Cuban Mulatto
Freq13 = 9.4 | People13 = Tunisia
Freq14 = 8.9 | People14 = Kenya Luo
Freq15 = 8.2 | People15 = Morocco Berber Nador Meta…
Freq16 = 8.1 | People16 = Zambia Lusaka
Freq17 = 7.5 | People17 = China Beijing
Freq18 = 7.1 | People18 = Kenya Nandi
Freq19 = 6.8 | People19 = Uganda Kampala
Freq20 = 6.7 | People20 = Georgia Tibilisi Kurds
Freq21 = 6.1 | People21 = Portugal South
Freq22 = 5.8 | People22 = Sudanese
Freq23 = 5.5 | People23 = Bulgaria
Freq24 = 5.5 | People24 = Israel Arab Druse
Freq25 = 5.4 | People25 = Saudi Arabia Guraiat and …
Freq26 = 4.6 | People26 = Spain Catalonia Girona
Freq27 = 4.5 | People27 = Kenya
Freq28 = 4.0 | People28 = Venezuela Caracus
Freq29 = 3.9 | People29 = USA South Texas Hispanics
Freq30 = 3.7 | People30 = Mexico Mestizos
Freq31 = 2.9 | People31 = Russia Tuva pop 2
Freq32 = 2.5 | People32 = Romanian
Freq33 = 2.3 | People33 = Croatia
Freq34 = 2.0 | People34 = Brazil
Freq35 = 2.0 | People35 = Spain Basque Gipuzkoa Pro…
Freq36 = 1.9 | People36 = Australia New South Wale…
Freq37 = 1.9 | People37 = Czech Republic
Freq38 = 1.9 | People38 = Georgia Tibilisi Georgian…
Freq39 = 1.7 | People39 = Oman
Freq40 = 1.6 | People40 = Belguim
Freq41 = 1.6 | People41 = USA North American Native…
Freq42 = 1.5 | People42 = China Inner Mongolia
Freq43 = 1.5 | People43 = India New Delhi
Freq44 = 1.5 | People44 = Pakistan Pathan
Freq45 = 1.4 | People45 = Ireland Northern
Freq46 = 1.4 | People46 = Jordan Amman
Freq47 = 1.4 | People47 = Mongolia Buriat
Freq48 = 1.3 | People48 = Pakistan Sindhi
Freq49 = 1.3 | People49 = USA Caucasian (2)
Freq50 = 1.2 | People50 = France South East
Freq51 = 1.2 | People51 = Italy North Pavia
Freq52 = 1.1 | People52 = Iran Baloch
Freq53 = 1.1 | People53 = Italy Bergamo
Freq54 = 1.0 | People54 = France Corsica
Freq55 = 1.0 | People55 = India North Hindus
Freq56 = 1.0 | People56 = Portugal Centre

Haplotypes

A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.

Associated diseases

A*23:Cw*07 is associated with higher viral load in HIVcite journal | author = Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R | title = Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. | journal = J Virol | volume = 76 | issue = 16 | pages = 8276–84 | year = 2002 | pmid = 12134033 | doi = 10.1128/JVI.76.16.8276-8284.2002]

References