Kelch protein

Protein
Name= Kelch protein


caption=
Symbol=IGF1
AltSymbols=
HGNCid=5464
Chromosome=
Arm
Band=
LocusSupplementaryData=-q23
ECnumber=
OMIM=147440
EntrezGene=3479
RefSeq=NM_000618
UniProt=P01343
PDB=1gof

Kelch proteins (and Kelch-like proteins) are proteins that have repeated kelch domains. Most Kelch proteins also have a BTB (defn) domain. Each kelch domain forms the blade of a propellar structure, with the repeated kelch domains forming a Beta-propellar. The structure of this Beta-propellar is known but the function is not characterised.

tructure

The N-terminus of Kelch proteins has a BTB (broad-complex, tram-track and bric-a-brac) domainThe BTB domain of kelch proteins (if present) allows the formation of homo- or heterodimers such that it mediated protein-protein interactions.

The C-terminus of Kelch proteins contains kelch repeats. Each kelch repeat motif is a 44-55 amino acid long peptide, usually occurring in clusters of 4 -7 repeats, forming a kelch domian.

Each kelch repeat forms a β-sheet secondary structure and forms a single 'blade' of the β-propellar tertiary structure that characterises Kelch domains. Traditionally, kelch domains have been found to have an affinity for actin filaments of a cell.

Function

The function of Kelch proteins is unknown. However they commonly seen to associate with actin tails

Organisms

The first Kelch protein (from which this family derives its name) was isolated from "Drosophila". It has also been isolated in many other animals [INSERT] , bacteria, fungi, and even virus (restricted to "Poxviridae")

Poxviruses:

Cowpox: 6 (D11L, C18L, G3L, A57R)

Ectromelia: 4 (Named due to high % sequence identity to Vaccinia proteins)

– A55R (EMV150)

– C2L

– F3L

– A55RD (divergent to A55R, with low sequence identity)

Vaccinia: 3

– A55R

– C2L

– F3L

Monkeypox: 1

Variola: 0 (with partial Kelch domains, however none are functional)

Humans:

Causes a neuropathy disease

Genes

Ectromelia Virus

A55R (EVM150)

ATGAATAACA GCAGTGAATT AATTGCTGCG ATTAATGGAT TTAGAAATAG TGGACGATTT TGTGATATTA ATATAGTTATTAATGATGAA AGGATAAATG CTCATAGACT CATCCTATCT GGAGCATCCG AATATTTTTC CATTCTATTT TCTAGTGATTTTATCGATTC TAATGAATAC GAAGTTAATC TAAGTCATTT AGATTATCAA AGTGTGAACG ATTTGATCGA TTACATTTATGGGATACCTT TGAGCCTAAC TAACGATAGC GTGAAATATA TTCTTTCAAC TGCTGATTTT TTACAAATTG GATCTGCTATTACGGAGTGT GAAAATTACA TACTTAAAAA TCTCTGTTCT AGAAACTGTA TCGATTTCTA CATATACGCT GATAAATATAATAACAAGAA AATAGAAACA GCGTCGTTTA ACACAATATT ACGAAATATT TTGAGACTCA TTAACGATGA AAACTTTAAATACTTGACAG AGGAATCAAT GATAAAAATT TTAAGCGATG ATATGTTAAA TATAAAAAAT GAGGATTTCG CACCACTAATTCTCATTAAA TGGTTAGAGA GTACACAACA ACCATGCACC GTCGAGTTAC TTAGATGCCT CAGAATATCA TTGCTTTCCCCACAAGTTAT AAAATCACTT TATAGTCATC GACTGGTTAG TTCAATCTAC GAATGTATAA CATTCTTAAA CAATATAGCATTCTTGGATG AATCATTTCC TAGATACAAT AGCATCGAGT TGATATCTAT CGGTATAAGT AATTCACGTG ATAAGATTTCCATAAACTGC TACAATCGTA AAAAAAATAC ATGGGAAATG ATATCTTCAC GTGGATATAG GTGTAGTTTC GCAGTGGCTGTCATGGATAA TATTATCTAT ATGATGGGTG GATACGATCA GTCCCCGTAT AGAAGTTCAA AGGTTATAGC ATACAATACATGTACTAATT CTTGGATATA TGATATACCA GAGCTAAAAT ATCCGCGTTC TAATTGCGGA GGAGTTGTCG ATGACGAATACATTTATTGT ATAGGTGGCA TACGCGATCA GGATTCATCG TTGATATCTG ATATTGATAG ATGGAAGCCA TCAAAACCATATTGGCAGAC GTATGCTAAA ATGCGAGAGC CAAAATGTGA TATGGGGGTT GCGATGTTAA ACGGATTAAT ATATGTCATAGGTGGAGTCG TTAAAGGTGG CACATGTACC GACACACTAG AGAGTTTATC AGAAGATGGA TGGATGATGC ATCGACGCCTTCCAATAAAA ATGTCCAATA TGTCGACGAT TGTTCATGCT GGAAAGATTT ATATATCTGG AGGTTACACC AATAGTAGTATAGTTAATGA AATATCTAAT CTAGTCCTTA GCTATAATCC GATATATGAT GAATGGACCA AATTATCATC ATTAAATATTCCTAGAATTA ATCCTGCTCT ATGGTCAGTG CATAATAAAT TATATGTAGG AGGAATATCC GATGATGTTC AAACTAATACATCTGAAACA TACGACAAAG AAAAAGATTG TTGGACATTG GATAATGGTC ACGTGTTACC ATACAATTAT ATAATGTATAAATGCGAACC GATTAAACAT AAATATCCAT TGGAAAAAAT ACAGTACACG AATGATTTTC TAAAGTGTTT GGAGAGTTTTATAGGTAGTT GA

C2L (EVM018)

ATGGAAAGCG TGATATTTTC TATCAATGGG GAAATTATAC AAGTGAATAA GGAAATTATT ACGGCGTCTC CGTATAATTTGTTTAAACGC ATTCAGGATC ACCATCTAAA GGATGAAGCG ATTATATTGA ATGGTATAAA CTATCACGCG TTTGAATCGCTATTAGACTA TATGCGCTGG AAGAAGATAA ACATCACCAT AAACAATGTA GAAATGATAC TAGTTGCTGC CATAATAATTGATGTTCCGC CTGTAGTAGA TCTATGTGTA AAAACTATGA TTCATAATAT TAATTCCACA AATTGTATAA GGATGTTTAACTTTTCTAAA AGATATGGAA TTAAAAAACT ATATAATGCG TCGATGTCAG AAATAATCAA CAATATTACA GCGGTGACATCCGATCCAGA ATTTGGAAAA TTATCAAAGG ATGAACTAAC AACTATCTTA TCCCACGAAA ACGTTAACGT AAATCATGAGGATGTTACAG CTATAATATT ATTAAAGTGG ATACATAAAA ATCCAAACGA TGTAGATATC ATCAACATTT TACATCCCAAGTTTATGACT AATGCTATGC GCAATGCTAT AGCATTGTTG GGATTAACTA TATCCAAATC TACAAAGCCT GTGACACGAAATGGTATAAA ACATAATATA GTAGTCATTA AAAACTCTGA TTATATATCC ACAATAACCC ATTACTCTCC TAGAACAGAATATTGGACGA TAGTCGGTAA TACAGATAGA CAATTCTATA ATGCAAATGT TTTACATAAT TGTCTATACA TTATTGGCGGCATGATTAAC AATAGACATG TTTATTCCGT ATCGCGGGTA GATCTTAAAA CGAAAAAATG GAAAACGGTC ACTAATATGTCGTCGTTAAA ATCAGAAGTT AGTACTTGTG TTAACAATGG AAAGTTATAT GTAATAGGAG GATTAGAATT TTCTATTTCAACGGCTGTAG CAGAATATTT GAAACATGGC GCTTCGAAAT GGATAAGACT TCCAAACTTA ATTACTCCTA GATATTCAGGAGCATCGGTA TTCGTAAACG ATGATATATA TGTAATGGGT GGAGTTTATA CCACGTATGA GAAATATGTA GTATTAAATGATGTGGAATG TTTCACTAAA AATCGTTGGA TAAAAAAGTC TCCCATGCCT AGACATCATA GTATAGTTTA TGCTGTAGAGTACGATGGTG ACATCTATGC AATTACTGGA ATTACTCATG AGACTCGTAA TTATCTATAC AAATATATAG TTAATGAAGACAAATGGATA GAATTATACA TGTACTTTAA CCATGTAGGA AAGATGTTCG TGTGTTCTTG TGGTGATTAT ATCTTAATTATAGCAGATGC AAAATACGAA TATTATCCAA AATCAAATAC TTGGAATTTG TTAGATACGT CAACTCGTAA TATCGAATATTATGATATGT TTACTAAAGA TGAGACTCCA AAATGTAATG TAACTCATAA GTCACTACCA TCGTTTTTGA GCAACTGTGAAAAAAAATTC CTACAATAG

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