KEAP1

Kelch-like ECH-associated protein 1, also known as KEAP1, is a human gene.cite web | title = Entrez Gene: KEAP1 kelch-like ECH-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9817| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.cite web | title = Entrez Gene: KEAP1 kelch-like ECH-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9817| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang DD |title=Mechanistic studies of the Nrf2-Keap1 signaling pathway. |journal=Drug Metab. Rev. |volume=38 |issue= 4 |pages= 769–89 |year= 2007 |pmid= 17145701 |doi= 10.1080/03602530600971974
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Itoh K, Wakabayashi N, Katoh Y, "et al." |title=Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 76–86 |year= 1999 |pmid= 9887101 |doi=
*cite journal | author=Dhakshinamoorthy S, Jaiswal AK |title=Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. |journal=Oncogene |volume=20 |issue= 29 |pages= 3906–17 |year= 2001 |pmid= 11439354 |doi= 10.1038/sj.onc.1204506
*cite journal | author=Sekhar KR, Spitz DR, Harris S, "et al." |title=Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. |journal=Free Radic. Biol. Med. |volume=32 |issue= 7 |pages= 650–62 |year= 2002 |pmid= 11909699 |doi=
*cite journal | author=Velichkova M, Guttman J, Warren C, "et al." |title=A human homologue of Drosophila kelch associates with myosin-VIIa in specialized adhesion junctions. |journal=Cell Motil. Cytoskeleton |volume=51 |issue= 3 |pages= 147–64 |year= 2002 |pmid= 11921171 |doi= 10.1002/cm.10025
*cite journal | author=Zipper LM, Mulcahy RT |title=The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36544–52 |year= 2002 |pmid= 12145307 |doi= 10.1074/jbc.M206530200
*cite journal | author=Sekhar KR, Yan XX, Freeman ML |title=Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. |journal=Oncogene |volume=21 |issue= 44 |pages= 6829–34 |year= 2002 |pmid= 12360409 |doi= 10.1038/sj.onc.1205905
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bloom DA, Jaiswal AK |title=Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44675–82 |year= 2004 |pmid= 12947090 |doi= 10.1074/jbc.M307633200
*cite journal | author=Cullinan SB, Zhang D, Hannink M, "et al." |title=Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7198–209 |year= 2003 |pmid= 14517290 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Kobayashi A, Kang MI, Okawa H, "et al." |title=Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. |journal=Mol. Cell. Biol. |volume=24 |issue= 16 |pages= 7130–9 |year= 2004 |pmid= 15282312 |doi= 10.1128/MCB.24.16.7130-7139.2004
*cite journal | author=Strachan GD, Morgan KL, Otis LL, "et al." |title=Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. |journal=Biochemistry |volume=43 |issue= 38 |pages= 12113–22 |year= 2004 |pmid= 15379550 |doi= 10.1021/bi0494166
*cite journal | author=Li X, Zhang D, Hannink M, Beamer LJ |title=Crystal structure of the Kelch domain of human Keap1. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54750–8 |year= 2005 |pmid= 15475350 |doi= 10.1074/jbc.M410073200
*cite journal | author=Zhang DD, Lo SC, Cross JV, "et al." |title=Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10941–53 |year= 2004 |pmid= 15572695 |doi= 10.1128/MCB.24.24.10941-10953.2004
*cite journal | author=Li X, Zhang D, Hannink M, Beamer LJ |title=Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 12 Pt 2 |pages= 2346–8 |year= 2005 |pmid= 15583386 |doi= 10.1107/S0907444904024825
*cite journal | author=Furukawa M, Xiong Y |title=BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. |journal=Mol. Cell. Biol. |volume=25 |issue= 1 |pages= 162–71 |year= 2005 |pmid= 15601839 |doi= 10.1128/MCB.25.1.162-171.2005
*cite journal | author=Hosoya T, Maruyama A, Kang MI, "et al." |title=Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27244–50 |year= 2005 |pmid= 15917255 |doi= 10.1074/jbc.M502551200

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