Thiolutin

drugbox
IUPAC_name = N-(8-methyl-7-oxo-3,4-dithia-8-azabicyclo [3.3.0] octa-1,5-dien-6-yl)acetamide


CAS_number = 87-11-6
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PubChem = 6870
DrugBank =
C=8|H=8|N=2|O=2|S=2
molecular_weight = 228.293 g/mol
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Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit "in vitro" RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in "Saccharomyces cerevisiae" and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

Thiolutin is formed in submerged fermentation by several strains of Streptomycetes (source: Fermentek [http://www.fermentek.co.il/thiolutin.htm product page] )

Synonyms: farcinicin, propiopyvothine, acetopyrrothine

Some sources erroneously specify "aureothricin" as a synonym of thiolutin. Aureothricin is an antibiotic very similar to Thiolutin, and is created as a by-product during the Thiolutin fermentation.

References

* [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17036064&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor.]