2-Methoxyestradiol

2-Methoxyestradiol

Systematic (IUPAC) name
(8R,9S,13S,14S,17S)-2-methoxy- 13-methyl-6,7,8,9,11,12,14,15,16,17- decahydrocyclopenta[a]phenanthrene-3,17-diol
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	362-07-2 N
ATC code	?
PubChem	CID 66414
ChemSpider	59788 Y
UNII	6I2QW73SR5 Y
ChEBI	CHEBI:28955 Y
ChEMBL	CHEMBL299613 Y
Chemical data
Formula	C19H26O3
Mol. mass	302.408 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1 Y Key:CQOQDQWUFQDJMK-SSTWWWIQSA-N Y
N(what is this?)  (verify)

2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It is derived from estrogen, although it binds poorly to known estrogen receptors, and belongs to the family of drugs called angiogenesis inhibitors. It has undergone Phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol. It also acts as a vasodilator. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.

External links

• Chemical Information and Structure from the Comparative Toxicogenomics Database
• Phase 1 trials
• EntreMed's Product Information Site

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