- PB28
Chembox new
Name = PD28
ImageFile = PD28.png
ImageName = PD28
IUPACName = {IUPAC|1-cyclohexyl-4- [3-(5-methoxy-1,2,3,4-tetra-hydronaphthalen-1-yl)propyl] piperazine}
OtherNames = PD28
Section1 = Chembox Identifiers
CASNo =
SMILES = COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1
Section2 = Chembox Properties
Formula = C24H38N2O
MolarMass = 370.57 g/molPB28cite journal | author = Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L | title = New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives | journal = J. Med. Chem. | volume = 39 | issue = 1 | pages = 176–82 | year = 1996 | pmid = 8568804 | doi = 10.1021/jm950409c | issn = ] is an agonist of the
sigma-2 receptor .cite journal | author = Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA | title = The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells | journal = Cell Calcium | volume = 40 | issue = 1 | pages = 23–8 | year = 2006 | pmid = 16687172 | doi = 10.1016/j.ceca.2006.03.004 | issn = ] cite journal | author = Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A | title = Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer | journal = Mol. Cancer Ther. | volume = 5 | issue = 7 | pages = 1807–16 | year = 2006 | pmid = 16891467 | doi = 10.1158/1535-7163.MCT-05-0402 | issn = ]It is derived from
cyclohexylpiperazine .References
External links
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