PC12 cells

PC12 is a cancer cell line derived from a pheochromocytoma of the rat adrenal medulla.cite journal | author = Greene LA, Tischler AS | title = Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 73 | issue = 7 | pages = 2424–8 | year = 1976 | month = July | pmid = 1065897 | pmc = 430592 | url = | issn = ] cite web | url = http://www.lgcpromochem-atcc.com/common/catalog/numSearch/numResults.cfm?atccNum=CRL-1721 | title = PC-12/CRL-1721 cell line | author = | authorlink = | coauthors = | date = | format = | work = LGC Promochem: Cell Biology Collection | publisher = American Type Culture Collection | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-08-15] PC12 cells stop dividing and terminally differentiate when treated with nerve growth factor. This makes PC12 cells useful as a model system for neuronal differentiation.

See also

* Cell culture
* adrenal medulla
* Cellular differentiation

References

External links

* Wikipedia articles containing the term "PC12 cells" [http://www.google.de/search?hl=en&lr=&ie=ISO-8859-1&q=site%3Aen.wikipedia.org%20PC12%20cells&btnG=Google+Search]
* table of common cell lines including PC12 [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.table.1515] , from Alberts 4th edition at NCBI bookshelf
* Ras function was partially elucidated using PC12 cell line [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=PC12&rid=cmed6.section.1080%231085&WebEnv=0HOhQ10ImJdCL8QWhv8jmakihA5e0QxWqJ9y9n6jvarcLiUb7GMU98BOrUDQVrkDGg5Ona-7T5nkW-%40D45D6EC76612AEB0_0018SID&WebEnvRq=1] , from section in Cancer Medicine textbook
* Section on neural transmission [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=PC12&rid=bnchm.section.688#697] has several references to PC12 cell line