PIK3C2G

Phosphoinositide-3-kinase, class 2, gamma polypeptide, also known as PIK3C2G, is a human gene.cite web | title = Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5288| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.cite web | title = Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5288| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee C, Liu QH, Tomkowicz B, "et al." |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206
*cite journal | author=Milani D, Mazzoni M, Borgatti P, "et al." |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=
*cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=
*cite journal | author=Borgatti P, Zauli G, Colamussi ML, "et al." |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=
*cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=
*cite journal | author=Misawa H, Ohtsubo M, Copeland NG, "et al." |title=Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 531–9 |year= 1998 |pmid= 9514948 |doi= 10.1006/bbrc.1998.8294
*cite journal | author=Ono F, Nakagawa T, Saito S, "et al." |title=A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7731–6 |year= 1998 |pmid= 9516481 |doi=
*cite journal | author=Milani D, Mazzoni M, Zauli G, "et al." |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=
*cite journal | author=Jauliac S, Mazerolles F, Jabado N, "et al." |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=
*cite journal | author=Rozycka M, Lu YJ, Brown RA, "et al." |title=cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. |journal=Genomics |volume=54 |issue= 3 |pages= 569–74 |year= 1999 |pmid= 9878262 |doi= 10.1006/geno.1998.5621
*cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=
*cite journal | author=Zauli G, Milani D, Mirandola P, "et al." |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com
*cite journal | author=Deregibus MC, Cantaluppi V, Doublier S, "et al." |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200
*cite journal | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi=
*cite journal | author=François F, Klotman ME |title=Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2539–49 |year= 2003 |pmid= 12551992 |doi=
*cite journal | author=Khan NA, Di Cello F, Nath A, Kim KS |title=Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. |journal=J. Neurovirol. |volume=9 |issue= 6 |pages= 584–93 |year= 2004 |pmid= 14602571 |doi=
*cite journal | author=Langford D, Hurford R, Hashimoto M, "et al." |title=Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120. |journal=BMC neuroscience |volume=6 |issue= 1 |pages= 8 |year= 2006 |pmid= 15689238 |doi= 10.1186/1471-2202-6-8
*cite journal | author=Lee C, Tomkowicz B, Freedman BD, Collman RG |title=HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. |journal=J. Leukoc. Biol. |volume=78 |issue= 4 |pages= 1016-23 |year= 2006 |pmid= 16081599 |doi= 10.1189/jlb.0105056
*cite journal | author=Anand AR, Ganju RK |title=HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12289–99 |year= 2006 |pmid= 16524887 |doi= 10.1074/jbc.M511786200

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