GRB10

Growth factor receptor-bound protein 10, also known as GRB10, is a human gene.cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = ]

PBB_Summary
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summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H |title=Severe Silver-Russell syndrome and translocation (17;20) (q25;q13) |journal=Clin. Genet. |volume=41 |issue= 1 |pages= 51–3 |year= 1992 |pmid= 1633648 |doi=
*cite journal | author=Liu F, Roth RA |title=Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10287–91 |year= 1995 |pmid= 7479769 |doi=
*cite journal | author=Pandey A, Duan H, Di Fiore PP, Dixit VM |title=The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21461–3 |year= 1995 |pmid= 7665556 |doi=
*cite journal | author=Midro AT, Debek K, Sawicka A, "et al." |title=Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25. |journal=Clin. Genet. |volume=44 |issue= 1 |pages= 53–5 |year= 1993 |pmid= 8403458 |doi=
*cite journal | author=Hansen H, Svensson U, Zhu J, "et al." |title=Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8882–6 |year= 1996 |pmid= 8621530 |doi=
*cite journal | author=Morrione A, Valentinis B, Li S, "et al." |title=Grb10: A new substrate of the insulin-like growth factor I receptor. |journal=Cancer Res. |volume=56 |issue= 14 |pages= 3165–7 |year= 1996 |pmid= 8764099 |doi=
*cite journal | author=O'Neill TJ, Rose DW, Pillay TS, "et al." |title=Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22506–13 |year= 1996 |pmid= 8798417 |doi=
*cite journal | author=Stein E, Cerretti DP, Daniel TO |title=Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23588–93 |year= 1996 |pmid= 8798570 |doi=
*cite journal | author=Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE |title=Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2659–67 |year= 1997 |pmid= 9006901 |doi=
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=Jerome CA, Scherer SW, Tsui LC, "et al." |title=Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12. |journal=Genomics |volume=40 |issue= 1 |pages= 215–6 |year= 1997 |pmid= 9070953 |doi= 10.1006/geno.1996.4535
*cite journal | author=Dong LQ, Du H, Porter SG, "et al." |title=Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29104–12 |year= 1997 |pmid= 9360986 |doi=
*cite journal | author=He W, Rose DW, Olefsky JM, Gustafson TA |title=Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6860–7 |year= 1998 |pmid= 9506989 |doi=
*cite journal | author=Nantel A, Mohammad-Ali K, Sherk J, "et al." |title=Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10475–84 |year= 1998 |pmid= 9553107 |doi=
*cite journal | author=Moutoussamy S, Renaudie F, Lago F, "et al." |title=Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 15906–12 |year= 1998 |pmid= 9632636 |doi=
*cite journal | author=Bai RY, Jahn T, Schrem S, "et al." |title=The SH2-containing adapter protein GRB10 interacts with BCR-ABL. |journal=Oncogene |volume=17 |issue= 8 |pages= 941–8 |year= 1998 |pmid= 9747873 |doi= 10.1038/sj.onc.1202024
*cite journal | author=Mano H, Ohya K, Miyazato A, "et al." |title=Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase. |journal=Genes Cells |volume=3 |issue= 7 |pages= 431–41 |year= 1998 |pmid= 9753425 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Angrist M, Bolk S, Bentley K, "et al." |title=Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. |journal=Oncogene |volume=17 |issue= 23 |pages= 3065–70 |year= 1999 |pmid= 9881709 |doi= 10.1038/sj.onc.1202226
*cite journal | author=Wang J, Dai H, Yousaf N, "et al." |title=Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6217–28 |year= 1999 |pmid= 10454568 |doi=

External links

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