GRB14

Growth factor receptor-bound protein 14, also known as GRB14, is a human gene.cite web | title = Entrez Gene: GRB14 growth factor receptor-bound protein 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2888| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.cite web | title = Entrez Gene: GRB14 growth factor receptor-bound protein 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2888| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Han DC, Shen TL, Guan JL |title=The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. |journal=Oncogene |volume=20 |issue= 44 |pages= 6315–21 |year= 2001 |pmid= 11607834 |doi= 10.1038/sj.onc.1204775
*cite journal | author=Daly RJ, Sanderson GM, Janes PW, Sutherland RL |title=Cloning and characterization of GRB14, a novel member of the GRB7 gene family. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12502–10 |year= 1996 |pmid= 8647858 |doi=
*cite journal | author=Baker E, Sutherland GR, Sutherland RL, Daly RJ |title=Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization. |journal=Genomics |volume=36 |issue= 1 |pages= 218–20 |year= 1997 |pmid= 8812444 |doi= 10.1006/geno.1996.0453
*cite journal | author=Kasus-Jacobi A, Perdereau D, Auzan C, "et al." |title=Identification of the rat adapter Grb14 as an inhibitor of insulin actions. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26026–35 |year= 1998 |pmid= 9748281 |doi=
*cite journal | author=Jones N, Master Z, Jones J, "et al." |title=Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30896–905 |year= 1999 |pmid= 10521483 |doi=
*cite journal | author=Reilly JF, Mickey G, Maher PA |title=Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7771–8 |year= 2000 |pmid= 10713090 |doi=
*cite journal | author=Hemming R, Agatep R, Badiani K, "et al." |title=Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins. |journal=Biochem. Cell Biol. |volume=79 |issue= 1 |pages= 21–32 |year= 2001 |pmid= 11235915 |doi=
*cite journal | author=Lyons RJ, Deane R, Lynch DK, "et al." |title=Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17172–80 |year= 2001 |pmid= 11278563 |doi= 10.1074/jbc.M009756200
*cite journal | author=Béréziat V, Kasus-Jacobi A, Perdereau D, "et al." |title=Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4845–52 |year= 2002 |pmid= 11726652 |doi= 10.1074/jbc.M106574200
*cite journal | author=Cariou B, Perdereau D, Cailliau K, "et al." |title=The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 6959–70 |year= 2002 |pmid= 12242277 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=King CC, Newton AC |title=The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37518–27 |year= 2004 |pmid= 15210700 |doi= 10.1074/jbc.M405340200
*cite journal | author=Scharf PJ, Witney J, Daly R, Lyons BA |title=Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain. |journal=Protein Sci. |volume=13 |issue= 9 |pages= 2541–6 |year= 2005 |pmid= 15322292 |doi= 10.1110/ps.04884704
*cite journal | author=Kairouz R, Parmar J, Lyons RJ, "et al." |title=Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells. |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 85–93 |year= 2005 |pmid= 15372466 |doi= 10.1002/jcp.20199
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Depetris RS, Hu J, Gimpelevich I, "et al." |title=Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. |journal=Mol. Cell |volume=20 |issue= 2 |pages= 325–33 |year= 2006 |pmid= 16246733 |doi= 10.1016/j.molcel.2005.09.001
*cite journal | author=Park JJ, Berggren JR, Hulver MW, "et al." |title=GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. |journal=Physiol. Genomics |volume=27 |issue= 2 |pages= 114–21 |year= 2006 |pmid= 16849634 |doi= 10.1152/physiolgenomics.00045.2006

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes