Serine racemase

Serine racemase

protein
Name=serine racemase
caption=


width=
HGNCid=14398
Symbol=SRR
AltSymbols=
EntrezGene=63826
OMIM=606477
RefSeq=NM_021947
UniProt=Q9GZT4
PDB=
ECnumber=5.1.1.16
Chromosome=17
Arm=p
Band=13
LocusSupplementaryData=

Serine racemase is an enzyme which generates D-serine from L-serine. D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain.

Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, generating pyruvate and ammonoia. The enzyme is physiologically stimulated by divalent cations (e.g., magnesium) and is allosterically activated by the complex Mg,ATP.

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