U8 small nucleolar RNA

U8 small nucleolar RNA

U8 small nucleolar RNA (also known as SNORD118) is the RNA component of a small RNA:protein complex (the U8 snoRNP) which is required for biogenesis of mature large subunit ribosomal RNAs, 5.8S and 28S rRNAs cite journal | author = Peculis BA | title = The sequence of the 5' end of the U8 small nucleolar RNA is critical for 5.8S and 28S rRNA maturation | journal = Mol. Cell. Biol. | volume = 17 | issue = 7 | pages = 3702–13 | year = 1997 | pmid = 9199304 | doi = | issn = ] . cite journal | author = Peculis BA, DeGregorio S, McDowell K | title = The U8 snoRNA gene family: identification and characterization of distinct, functional U8 genes in Xenopus | journal = Gene | volume = 274 | issue = 1-2 | pages = 83–92 | year = 2001 | pmid = 11675000 | doi = | issn = ]

More specifically, U8 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U8 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

U8 RNA genes have been identified in human, mouse, rat and the amphibian "Xenopus laevis".

References

External links

*
* [http://www-snorna.biotoul.fr/plus.php?id=U8 snoRNABase entry for SNORD118]


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Small nucleolar RNA R38 — is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is …   Wikipedia

  • Small nucleolar RNA U6-53/MBII-28 — Small nucleolar RNA U6 53 (also known as MBII 28) is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic… …   Wikipedia

  • Small nucleolar RNA snoR60 — is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is …   Wikipedia

  • Small nucleolar RNA SNORD83 — (also known as U83 and U84) is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site …   Wikipedia

  • Small nucleolar RNA SNORA64/SNORA10 family — Small nucleolar RNA SNORA10 is homologous to SNORA64and belongs to the H/ACA class of small nucleolar RNAs (snoRNAs), a family of ncRNAs involved in the maturation of ribosomal RNA cite journal | author = Narayanan A, Lukowiak A, Jády BE, et al | …   Wikipedia

  • Small nucleolar RNA R24 — (also known as snoRNA R24) is a non coding RNA (ncRNA) molecule identified in plants which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell… …   Wikipedia

  • Small nucleolar RNA MBII-202 — is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is …   Wikipedia

  • Small nucleolar RNA Z50 — is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is… …   Wikipedia

  • Small nucleolar RNA R32/R81/Z41 — Small nucleolar RNA Z41 (homologous to R32 and R81) is a non coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic… …   Wikipedia

  • Small nucleolar RNA SNORA68 — (also known as U68) is a non coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site… …   Wikipedia

  • Small nucleolar RNA SNORA69 — (also known as U69) is a non coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”