Small nucleolar RNA R38

Small nucleolar RNA R38 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA R38 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .snoRNA R38 has been identified in human, yeastcite journal |author=Bachellerie JP, Michot B, Nicoloso M, Balakin A, Ni J, Fournier MJ |title=Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA |journal=Trends Biochem. Sci. |volume=20 |issue=7 |pages=261–4 |year=1995 |pmid=7667877 |doi=] , "Arabidopsis thaliana"cite journal |author=Qu LH, Meng Q, Zhou H, "et al" |title=Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana |journal=Nucleic Acids Res. |volume=29 |issue=7 |pages=1623–30 |year=2001 |pmid=11266566 |doi=] and "Oryza sativa"cite journal |author=Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH |title=The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa |journal=Nucleic Acids Res. |volume=31 |issue=10 |pages=2601–13 |year=2003 |pmid=12736310 |doi=] . snoRNA R38 guides the methylation of 2'-O-ribose sites in 28S rRNA.

References

External links

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* [http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/snr38_ta.php Yeast snoRNA page for Small nucleolar RNA R38]
* [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=snR38 SGD page for Small nucleolar RNA R38]