Small nucleolar RNA SNORD83

Small nucleolar RNA SNORD83 (also known as U83 and U84) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA SNORD83 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .snoRNA SNORD83 are spliced from introns 5 and 4 of the BAT1 gene in mammals [cite journal | author = Jady BE, Kiss T | title = Characterisation of the U83 and U84 small nucleolar RNAs: two novel 2'-O-ribose methylation guide RNAs that lack complementarities to ribosomal RNAs. | journal = Nucleic Acids Res | volume = 28 | issue = 6 | pages = 1348–54 | year = 2000 | pmid = 10684929 | doi = 10.1093/nar/28.6.1348] [cite journal | author = Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T | title = The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs. | journal = Biochim Biophys Acta | volume = 1490 | issue = 3 | pages = 225–36 | year = 2000 | pmid = 10684968] .

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External links

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* [http://www-snorna.biotoul.fr/plus.php?id=U83A snoRNAbase entry for U83]