Spi-1 (PU.1) 5' UTR regulatory element

The Spi-1 (PU.1) 5' UTR regulatory element is an RNA element found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia. [cite journal | last = Hensold | first = JO | coauthors = Stratton CA, Barth D | year = 1997 | title = The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo | journal = Nucleic Acids Res | volume = 25 | pages = 2869–2876 | pmid = 9207037 | doi = 10.1093/nar/25.14.2869]

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