Nanos 3' UTR translation control element

Nanos 3' UTR translation control element
Predicted secondary structure and sequence conservation of nos_TCE
Identifiers
Symbol	nos_TCE
Rfam	RF00161
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
GO	0008595 0017148 0005515
SO	0000205

Nanos 3' UTR translation control element is a cis-regulatory element in the 3' untranslated region (3'UTR) of the messenger RNA which encodes the Nanos protein. The Nanos protein in Drosophila is required for correct morphogenesis (anterior/posterior patterning) in the Drosophila embryo. Translation of the Nanos mRNA is repressed in the bulk cytoplasm and activated in the posterior region. The translation control element (TCE) in the 3'UTR forms a Y-shaped secondary structure, part of which is recognised by the Smaug protein and leads to translational repression.^[1]

References

1. ^ Crucs S, Chatterjee S, Gavis ER (2000). "Overlapping but distinct RNA elements control repression and activation of nanos translation". Mol. Cell 5 (3): 457–67. doi:10.1016/S1097-2765(00)80440-2. PMID 10882131. 

External links

• Rfam page for Nanos 3' UTR translation control element