MicC RNA

MicC RNA
Predicted secondary structure and sequence conservation of MicC
Identifiers
Symbol	MicC
Alt. Symbols	IS063
Rfam	RF00121
Other data
RNA type	Gene; sRNA
Domain(s)	Bacteria
SO	0000655

The MicC non-coding RNA (previously known as IS063 ^[1]) is located between the ompN and ydbK genes in E. coli. This RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5' region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli ^[2].

See also

• Two-component regulatory system

References

1. ^ Chen, S; Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Biosystems 65 (2–3): 157–177. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726. 
2. ^ Chen, S; Zhang A, Blyn LB, Storz G (2004). "MicC, a Second Small-RNA Regulator of Omp Protein Expression in Escherichia coli". J Bacteriol 186 (20): 6689–6697. doi:10.1128/JB.186.20.6689-6697.2004. PMC 522180. PMID 15466019. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522180. 

Further reading

• Pfeiffer, V.; Papenfort, K.; Lucchini, S.; Hinton, J. C. D.; Vogel, J. �R. (2009). "Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation". Nature Structural & Molecular Biology 16 (8): 840. doi:10.1038/nsmb.1631.  edit

External links

• Rfam page for MicC RNA