Hepatitis A virus internal ribosome entry site (IRES)
- Hepatitis A virus internal ribosome entry site (IRES)
This family represents the internal ribosome entry site (IRES) of the the Hepatitis A virus. [cite journal | last = Brown | first = EA | coauthors = Zajac AJ, Lemon SM | year = 1994 | title = In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus | journal = J Virol | volume = 68 | pages = 1066–1074 | pmid = 8289336] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for eukaryotic initiation factor, eIF4F. [cite journal | last = Kolupaeva | first = VG | coauthors = Pestova TV, Hellen CU | year = 2000 | title = Ribosomal binding to the internal ribosomal entry site of classical swine fever virus | journal = RNA | volume = 6 | pages = 1791–1807 | pmid = 11142379 | doi = 10.1017/S1355838200000662]
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