Hepatitis C alternative reading frame stem-loop

Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome. The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame(ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures [1] . The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication [1] . The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression [1] . These stem loops are located downstream of the Internal ribosome entry site (IRES) but their functional role is unknown [1] .

References

* [1] cite journal |author= McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD,Feinstone SM, Rice CM; |title= Evidence for a functional RNA element in the hepatitis C virus coregene. |journal= Proc Natl Acad Sci U S A |volume= 104 |issue= |pages= 2879–2884 |year= 2007 |pmid=17299041 |doi= 10.1073/pnas.0611267104

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