TLR 5

TLR 5

Toll-like receptor 5, also known as TLR5, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. [cite web | title = Entrez Gene: TLR5 toll-like receptor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7100| accessdate = ]

TLR5 recognizes flagellin. [cite web | title = Hayashi, F., et al., 2001| url = http://www.ncbi.nlm.nih.gov/pubmed/11323673] Flagellin is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5. [cite web | title = Smith, K.D., et al., 2003|url = http://www.ncbi.nlm.nih.gov/pubmed/14625549]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hayashi F, et al. |title=The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. |journal=Nature |volume=410 |issue=6832 |pages= 1099–1103 |year= 2001 |pmid= 11323673 |doi=
*cite journal | author=Lien E, Ingalls RR |title=Toll-like receptors. |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1–11 |year= 2002 |pmid= 11782555 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • TLR-2 — Masse/Länge Primärstruktur 784 Aminosäuren …   Deutsch Wikipedia

  • TLR 2 — is a biomolecule, which plays a role in the human immune system. TLR 2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes native or foreign substances, and passes on appropriate signals to the… …   Wikipedia

  • TLR 1 — is a member of the Toll like receptor family (TLR) of pattern recognition receptors of the innate immune system.cite journal | author = Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF | title = A family of human receptors structurally… …   Wikipedia

  • Tlr — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. {{{image}}}   Sigles d une seule lettre   Sigles de deux lettres > Sigles de trois lettres …   Wikipédia en Français

  • TLR — TLR: TLR  Двухобъективная зеркальная камера TLR  Толл подобные рецепторы Список значе …   Википедия

  • TLR 3 — is a member of the Toll like receptor family of pattern recognition receptors of the innate immune system. Discovered in 2001,cite journal | author = Alexopoulou L, Holt AC, Medzhitov R, Flavell RA | title = Recognition of double stranded RNA and …   Wikipedia

  • TLR — ist eine Abkürzung für folgende Begriffe: Air Libya, libysche Fluggesellschaft (ICAO Code) Toll like Receptor, ein Bestandteil des angeborenen Immunsystems Tonischer Labyrinth Reflex, ein frühkindlicher Reflex bei Säuglingen Twin Lens Reflex,… …   Deutsch Wikipedia

  • TLR — (three letter acronym) acronym composed of three letters (Internet Slang) …   English contemporary dictionary

  • TLR — The three letter abbreviation TLR can mean * Teaching and Learning Responsibility a category for the award of supplementary pay in teachers salaries in England* Toll like receptors, proteins constituting an important part of the immune system *… …   Wikipedia

  • TLR 7 — Toll like receptor 7, also known as TLR7, is an immune gene possessed by humans and other mammals and additionally in avian species. PBB Summary section title = summary text = The protein encoded by this gene is a member of the Toll like receptor …   Wikipedia

  • TLR 4 — Toll like receptor 4, also known as TLR4, is a human gene. TLR 4 is a toll like receptor. It detects lipopolysaccharide on Gram negative bacteria and is thus important in the activation of the innate immune system. TLR4 has also been designated… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”