TLR 5

TLR 5

Toll-like receptor 5, also known as TLR5, is a human gene.

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summary_text = The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. [cite web | title = Entrez Gene: TLR5 toll-like receptor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7100| accessdate = ]

TLR5 recognizes flagellin. [cite web | title = Hayashi, F., et al., 2001| url = http://www.ncbi.nlm.nih.gov/pubmed/11323673] Flagellin is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5. [cite web | title = Smith, K.D., et al., 2003|url = http://www.ncbi.nlm.nih.gov/pubmed/14625549]

References

Further reading

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citations =
*cite journal | author=Hayashi F, et al. |title=The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. |journal=Nature |volume=410 |issue=6832 |pages= 1099–1103 |year= 2001 |pmid= 11323673 |doi=
*cite journal | author=Lien E, Ingalls RR |title=Toll-like receptors. |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1–11 |year= 2002 |pmid= 11782555 |doi=

External links

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