Polymeric immunoglobulin receptor

Polymeric immunoglobulin receptor

Polymeric immunoglobulin receptor, also known as PIGR, is a human gene.

Polymeric immunoglobulin receptor is a Fc receptor which facilitates the secretion of IgA and IgM.

section_title =
summary_text = The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. [supplied by OMIM] cite web | title = Entrez Gene: PIGR polymeric immunoglobulin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5284| accessdate = ]


Further reading

citations =
*cite journal | author=Kaetzel CS |title=The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. |journal=Immunol. Rev. |volume=206 |issue= |pages= 83–99 |year= 2005 |pmid= 16048543 |doi= 10.1111/j.0105-2896.2005.00278.x
*cite journal | author=Krajci P, Kvale D, Taskén K, Brandtzaeg P |title=Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor) |journal=Eur. J. Immunol. |volume=22 |issue= 9 |pages= 2309–15 |year= 1992 |pmid= 1355431 |doi=10.1002/eji.1830220920
*cite journal | author=Krajci P, Grzeschik KH, Geurts van Kessel AH, "et al." |title=The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization. |journal=Hum. Genet. |volume=87 |issue= 6 |pages= 642–8 |year= 1991 |pmid= 1682231 |doi=10.1007/BF00201717
*cite journal | author=Eiffert H, Quentin E, Wiederhold M, "et al." |title=Determination of the molecular structure of the human free secretory component. |journal=Biol. Chem. Hoppe-Seyler |volume=372 |issue= 2 |pages= 119–28 |year= 1991 |pmid= 1859628 |doi=
*cite journal | author=Bakos MA, Kurosky A, Goldblum RM |title=Characterization of a critical binding site for human polymeric Ig on secretory component. |journal=J. Immunol. |volume=147 |issue= 10 |pages= 3419–26 |year= 1991 |pmid= 1940346 |doi=
*cite journal | author=Krajci P, Solberg R, Sandberg M, "et al." |title=Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues. |journal=Biochem. Biophys. Res. Commun. |volume=158 |issue= 3 |pages= 783–9 |year= 1989 |pmid= 2920039 |doi=10.1016/0006-291X(89)92790-3
*cite journal | author=Davidson MK, Le Beau MM, Eddy RL, "et al." |title=Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41. |journal=Cytogenet. Cell Genet. |volume=48 |issue= 2 |pages= 107–11 |year= 1989 |pmid= 3197448 |doi=10.1159/000132601
*cite journal | author=Hood L, Kronenberg M, Hunkapiller T |title=T cell antigen receptors and the immunoglobulin supergene family. |journal=Cell |volume=40 |issue= 2 |pages= 225–9 |year= 1985 |pmid= 3917857 |doi=10.1016/0092-8674(85)90133-3
*cite journal | author=Eiffert H, Quentin E, Decker J, "et al." |title= [The primary structure of human free secretory component and the arrangement of disulfide bonds] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=365 |issue= 12 |pages= 1489–95 |year= 1985 |pmid= 6526384 |doi=
*cite journal | author=Mizoguchi A, Mizuochi T, Kobata A |title=Structures of the carbohydrate moieties of secretory component purified from human milk. |journal=J. Biol. Chem. |volume=257 |issue= 16 |pages= 9612–21 |year= 1982 |pmid= 7107583 |doi=
*cite journal | author=Coyne RS, Siebrecht M, Peitsch MC, Casanova JE |title=Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31620–5 |year= 1995 |pmid= 7989333 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Piskurich JF, France JA, Tamer CM, "et al." |title=Interferon-gamma induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism. |journal=Mol. Immunol. |volume=30 |issue= 4 |pages= 413–21 |year= 1993 |pmid= 8455639 |doi=10.1016/0161-5890(93)90071-I
*cite journal | author=Piskurich JF, Youngman KR, Phillips KM, "et al." |title=Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma. |journal=Mol. Immunol. |volume=34 |issue= 1 |pages= 75–91 |year= 1997 |pmid= 9182878 |doi=10.1016/S0161-5890(96)00079-X
*cite journal | author=Hughes GJ, Frutiger S, Savoy LA, "et al." |title=Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor. |journal=FEBS Lett. |volume=410 |issue= 2-3 |pages= 443–6 |year= 1997 |pmid= 9237679 |doi=10.1016/S0014-5793(97)00629-7
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Ackermann LW, Wollenweber LA, Denning GM |title=IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells. |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5112–8 |year= 1999 |pmid= 10227981 |doi=
*cite journal | author=Røe M, Norderhaug IN, Brandtzaeg P, Johansen FE |title=Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction. |journal=J. Immunol. |volume=162 |issue= 10 |pages= 6046–52 |year= 1999 |pmid= 10229845 |doi=
*cite journal | author=Norderhaug IN, Johansen FE, Krajci P, Brandtzaeg P |title=Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3401–9 |year= 1999 |pmid= 10540352 |doi=10.1002/(SICI)1521-4141(199910)29:10<3401::AID-IMMU3401>3.0.CO;2-G
*cite journal | author=Hughes GJ, Reason AJ, Savoy L, "et al." |title=Carbohydrate moieties in human secretory component. |journal=Biochim. Biophys. Acta |volume=1434 |issue= 1 |pages= 86–93 |year= 1999 |pmid= 10556562 |doi=

External links


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