Intersalt study

The Intersalt study was a landmark observational study that showed a strong association between dietary salt and risk of cardiovascular disease. [cite journal | author=Intersalt Cooperative Research Group | title=Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion | journal=Br Med J | year=1988 | volume=297 | issue=6644 | pages=319–28 | pmid=3416162 ] The results were disputed by the Salt Institute (the salt producers' trade organisation), who demanded that the results be handed over for re-analysis. [cite journal | author=Godlee F | title=Editor's choice: Time to talk salt | journal=Br Med J | year=2007 | volume=334 | issue=7599 | doi=10.1136/bmj.39196.679537.47 | pages=0 ] A re-analysis was published in 1996 and the results were the same. [cite journal | author=Elliott P, Stamler J, Nichols R, "et al." | title=Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group | journal=Br Med J | year=1996 | volume=312 | issue=7041 | pages=1249–53 | pmid=8634612 ] The results have since been confirmed by the TOHP I and TOHP II studies. [cite journal | author=Cook NR, Cutler JA, Obarzanek E, "et al." | title=Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP) | journal=Br Med J | year=2007 | volume=334 | pages=885–8 | doi=10.1136/bmj.39147.604896.55 ]

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