Omapatrilat

Omapatrilat: Omapatrilat

Systematic (IUPAC) name

(4S,7S,10aS)-5-oxo-4-{[(2S)-3-phenyl-2- sulfanylpropanoyl]amino}-2,3,4,7,8,9,10,10a-octahydropyrido[6,1-b] [1,3]thiazepine-7-carboxylic acid

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 167305-00-2^Y

ATC code None

PubChem CID 656629

UNII 36NLI90E7T^N

ChEMBL CHEMBL289556^N

Chemical data

Formula C₁₉H₂₄N₂O₄S₂

Mol. mass 408.534 g/mol

N(what is this?) (verify)

Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.

This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns.^[1]

References

^ Joshi Venugopal. (2003) Pharmacological modulation of the natriuretic peptide system. Expert Opinion on Therapeutic Patents 13:9, 1389

Categories:
ACE inhibitors
Propionamides
Lactams
Thiols
Carboxylic acids
Antihypertensive agent stubs

Omapatrilat

Systematic (IUPAC) name
(4S,7S,10aS)-5-oxo-4-{[(2S)-3-phenyl-2- sulfanylpropanoyl]amino}-2,3,4,7,8,9,10,10a-octahydropyrido[6,1-b] [1,3]thiazepine-7-carboxylic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	167305-00-2^Y
ATC code	None
PubChem	CID 656629
UNII	36NLI90E7T^N
ChEMBL	CHEMBL289556^N
Chemical data
Formula	C₁₉H₂₄N₂O₄S₂
Mol. mass	408.534 g/mol
N(what is this?) (verify)

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

omapatrilat — noun An antihypertensive agent that inhibits both neutral endopeptidase and angiotensin converting enzyme … Wiktionary
Vasopeptidase-Inhibitoren — Omapatrilat, ein Vasopeptidaseinhibitor Vasopeptidase Inhibitoren sind potenzielle Arzneistoffe, die sowohl das Angiotensin Converting Enzyme (ACE) als auch die neutrale Endopeptidase (NEP) hemmen. Als Resultat der Hemmung des Angiotensin… … Deutsch Wikipedia
Lisinopril — v · d · e … Wikipedia
Vasopeptidaseinhibitoren — Vasopeptidase Inhibitoren sind eine Gruppe von blutdrucksenkenden Arzneistoffen, die sich dadurch auszeichnen, dass durch sie sowohl das Angiotensin Converting Enzyme (ACE) als auch die Neutrale Endopeptidase (NEP) gehemmt wird. So werden sowohl… … Deutsch Wikipedia
Atrial natriuretic peptide — protein Name = natriuretic peptide precursor A caption = width = HGNCid = 7939 Symbol = NPPA AltSymbols = ANP, PND EntrezGene = 4878 OMIM = 108780 RefSeq = NM 006172 UniProt = P01160 PDB = ECnumber = Chromosome = 1 Arm = p Band = 36.21… … Wikipedia
Neprilysin — Membrane metallo endopeptidase The structure of the neprilysin ectodomain in complex with a zinc chelating inhibitor. The zinc atom is shown as a gray sphere and the inhibitor is shown in green. Rendering based on 1r1h … Wikipedia
ACE-Hemmer — sind Arzneistoffe, die insbesondere in der Therapie des Bluthochdruckes (Hypertonie) und der chronischen Herzinsuffizienz Anwendung finden. Sie sind Hemmstoffe (Inhibitoren) des Angiotensin konvertierenden Enzyms (Angiotensin Converting Enzyme),… … Deutsch Wikipedia
OMA — object management architecture; omapatrilat … Medical dictionary
OMA — • object management architecture; • omapatrilat … Dictionary of medical acronyms & abbreviations

Academic Dictionaries and Encyclopedias

Omapatrilat

References

Look at other dictionaries:

Share the article and excerpts

Academic Dictionaries and Encyclopedias

Wikipedia

Omapatrilat

References

Look at other dictionaries:

Share the article and excerpts

Direct link