- TSPO (protein)
protein
Name=translocator protein (18kDa)
caption=
width=
HGNCid=1158
Symbol=TSPO
AltSymbols=BZRP
EntrezGene=706
OMIM=109610
RefSeq=NM_007311
UniProt=P30536
PDB=
ECnumber=
Chromosome=22
Arm=q
Band=13.3
LocusSupplementaryData=TSPO (Translocator Protein), also known as the peripheral benzodiazepine receptor (PBR), is a 18 kDa mitochondrial membrane protein.cite journal |author=Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M |title=Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function|journal=Trends Pharmacol Sci |volume= 27 |issue= 8|pages=402–9 |year= 2006 |pmid = 16822554 |doi=10.1016/j.tips.2006.06.005]
Functions
Imaging
Ligands of the TSPO are very useful for imaging of inflammation, for example, the ligand [3H] -
PK11195 has been used in receptorautoradiography to study neuroinflammation following brain injury.References
External links
*
Yeliseev, A.A. and Kaplan, S. (1995) A sensory transducer homologous to the mammalian peripheral-type benzodiazepine receptor regulates photosynthetic membrane complex formation in Rhodobacter sphaeroides 2.4.1. J. Biol. Chem., v. 270, p. 21167-21175
Yeliseev, A.A., Krueger, K.E., and Kaplan, S. (1997) Mammalian mitochondrial drug receptor functions as a bacterial "oxygen" sensor. Proc. Natl. Acad. Sci. USA, v. 94, p. 5101-5106.
Yeliseev, A. and Kaplan, S. (2000) TspO of Rhodobacter sphaeroides. A structural and functional model for the mammalian peripheral benzodiazepine receptor. J. Biol. Chem., v. 275, p. 5657-5674.
Yeliseev, A. and Kaplan, S. (1999) A novel mechanism for the regulation of photosynthesis geneexpression by the TspO outer membrane protein of Rhodobacter sphaeroides 2.4.1. J. Biol. Chem., v. 274, p. 21234-21243
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