David M. Gilbert

David M. Gilbert, PhD is J. Herbert Taylor Distinguished Professor of Molecular Biology in the Department of Biological Sciences at Florida State University. Dr. Gilbert's work focuses on the mechanisms regulating DNA replication during the cell cycle and the relationship between replication timing and structural and functional organization of chromosomes, most recently during differentiation in human and mouse embryonic stem cells. Dr. Gilbert received his BA degrees in Biochemistry/Cell Biology and Philosophy from the University of California at San Diego and his PhD in Genetics from Stanford University. He did two post-doctoral training periods, first as an EMBO Fellow with Pierre Chambon in Strasbourg, France studying transcriptional control and second as a Roche Fellow with Melvin DePamphilis studying replication origin recognition. He joined the faculty at State University of New York (SUNY) Upstate Medical University in 1994 and was appointed Full Professor in 2003. In 2006, he moved to Florida State University for his current Endowed Chair position and was elected as a Fellow and then Council Delegate of the American Association for the Advancement of Science (AAAS) in 2008 and 2010, respectively. Dr. Gilbert's awards include the American Cancer Society Junior Faculty Research Award (2000), the SUNY President's Young Investigator Award (2002) and the NIH Career Enhancement Award for Stem Cell Research (2004). He has served on American Cancer Society (1996-2004) and NIH study sections (1997-present) and is an editorial member of the Epigenetics Society and is on the editorial board of the Journal of Cell Biology.

ReplicationDomain

ReplicationDomain is a free online database resource for storing, sharing and visualizing DNA replication timing and transcription data, as well as other numerical epigenetic data types. Data is typically obtained from DNA microarrays or DNA sequencing. The site has a user registration system and registered users are allowed to upload their own data sets. Non-registered users may freely view and download public data sets, registered users may upload their own data sets and view them privately, share their data sets with other registered users, or make their data sets publicly available. In addition users can restrict sharing of their data sets to a user designated group of registered users.

History

The ReplicationDomain online database was envisioned by Dr. David Gilbert before his hiring at Florida State University in early 2006. Work on the project was started in August of 2006 and by November 2006 the first prototype, supporting only Mus Musculus species data, was online. Since those humble beginnings the site has added support for additional species data, support for additional epigenetic data types and granular support for sharing data sets with registered users. The ReplicationDomain staff in August 2006 was David Gilbert (Director), Alexander Stuy (System architect, database design and administrator, backend programmer), Nodin Weddington (Front end user interface programmer, database programmer, database design), Ichiro Hiratani (Interface designer, consultant, tester) and Tyrone Ryba (Interface designer, consultant, tester).

Site Usage Documentation

• General Navigation (Video) [1]
• Uploading Data Sets (Video) [2]

References

• BioMed Central - ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data [3]
• Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation[4]
• Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis.[5]
• G9a selectively represses a class of late-replicating genes at the nuclear periphery.[6]
• Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome.[7]
• Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome.[8]
• Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types.[9]

External links

• Florida State University faculty profile
• ReplicationDomain

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Name	Gilbert, David M.
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