Dullard protein

Dullard is a member of DXDX(T/V) phosphatase family, and was shown in 2002 to be a potential regulator of neural tube development in Xenopus.^[1]

Human Dullard and the yeast protein Nem1p perform similar functions in mammalian cells and yeast cells, respectively. Human Dullard can rescue the aberrant nuclear envelope morphology of nem1Delta yeast cells, functionally replacing Nem1p. Dullarddephosphorylates the mammalian phospatidic acid phosphatase, lipid. Dullard participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and that this cascade is conserved from yeast to mammals.

References

1. ^ Satow R, Chan TC, Asashima M (2002) Biochem Biophys Res Commun 295:85-91