- Serous tumour
Serous tumours are part of the
surface epithelial-stromal tumourgroup of ovarian neoplasms.They are common neoplasms with a strong tendency to bilaterality, and they account for 50% of all ovarian tumours.Sixty percent are benign, 10% are borderline and 30% are malignant.
"Benign" serous tumours are
unilocular(have one lobe); however if very large may be multilocular, contain clear fluid and have a smooth lining composed of columnar epithelial cells with cilia. Surgery is curative.In "borderline" lesions, the cyst or surface is lined by papillary structures, which are often very complex. Surgery is usually curative.
Microscopically, stromal papillae are covered by atypical
epithelial cells, but stromal invasion is absent, nuclear stratification is present."Malignant" serous tumours are solid, may be cystic and often show hemorrhageand necrosis. They are lined by a complex papillary pattern with presence of nuclear anaplasia. Serous carcinomas often have bulky peritoneal and omental metastases, and spread to the lymph nodes is frequent.
Unsurprisingly, 5-year survival decreases as the stage increases.There is a 25%
survival ratewith a stage III serous carcinoma.Staging:
Stage I - Tumor growth limited to ovaries.Stage II - Growth involving one or both ovaries with pelvic extension.Stage III - Tumor involving one or both ovaries with implants outside pelvis.Stage IV- Tumor involving one or both ovaries with presence of distant metastasis.
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