Gestational choriocarcinoma
- Gestational choriocarcinoma
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female.Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy.Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years.
Diagnosis
Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast.
Outcome
At the time of diagnosis, more than 90% of patients already have lung metastases, though there are also less frequent metastases to the brain and liver.With chemotherapy, there is an 80% 5-year survival rate.Ultimately, death is related to liver and brain metastases.
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Gestational trophoblastic disease — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 2602 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = 001496 eMedicineSubj = med eMedicineTopic = 866 MeshID = D031901 Gestational trophoblastic disease is any type of abnormal proliferation of… … Wikipedia
Choriocarcinoma — A highly malignant tumor that arises from trophoblastic cells within the uterus. Choriocarcinoma tends to be invasive and to metastasize early and widely through both the venous and lymphatic systems. Choriocarcinoma is one of the two types of… … Medical dictionary
gestational trophoblastic disease — Any of a group of tumors that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. The two main types of gestational trophoblastic diseases are… … English dictionary of cancer terms
gestational trophoblastic tumor — Any of a group of tumors that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. The two main types of gestational trophoblastic tumors are… … English dictionary of cancer terms
gestational trophoblastic neoplasia — (GTN) a group of neoplastic disorders that originate in the placenta, including the benign hydatidiform mole and the malignant chorioadenoma destruens and choriocarcinoma. Called also gestational trophoblastic disease and trophoblastic disease … Medical dictionary
choriocarcinoma — A malignant, fast growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta). Almost all choriocarcinomas form in the uterus after fertilization of an egg by a sperm, but a… … English dictionary of cancer terms
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pregnancy — /preg neuhn see/, n., pl. pregnancies. the state, condition, or quality of being pregnant. [1520 30; PREGN(ANT) + ANCY] * * * Process of human gestation that takes place in the female s body as a fetus develops, from fertilization to birth (see… … Universalium
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