- Peptide sequence
Peptide sequence or amino acid sequence is the order in which
amino acid residues, connected bypeptide bond s, lie in the chain inpeptide s andprotein s. The sequence is generally reported from the N-terminal end containing freeamino group to the C-terminal end containing freecarboxyl group . Peptide sequence is often called protein sequence if it represents theprimary structure of aprotein .Sequence notation and applications
Many peptide sequences have been n
sequence database s. These databases may use various notations to describe the peptide sequence. The full names of the amino acids are rarely given; instead, 3-letter or 1-letter abbreviations are usually recorded for conciseness.Several deductions can be made from the sequence itself. Long stretches of
hydrophobic residues may indicate transmembrane helices. These helices may indicate the peptide is acell receptor . Certain residues indicate abeta sheet area. If full-length protein sequence is available, it is possible to estimate theisoelectric point of the protein. Methods for determining the peptide sequence include deduction fromDNA sequence,Edman degradation , andmass spectrometry .Techniques in
sequence analysis can be applied to learn more about the peptide. These techniques generally consist of comparing the sequence to other sequences from sequence databases. Other sequences may have already been studied and determined to be significant. Findings about these sequences may be applicable to the sequence under investigation.See also
*
Protein
*Protein sequencing
*Rosetta@home
*SIMAP External links
* [http://www.nslij-genetics.org/dnacorr/ A bibliography on features, patterns, correlations in DNA and protein texts]
Wikimedia Foundation. 2010.
