Shope papilloma virus

Shope papilloma virus
Virus classification
Group:	Group I (dsDNA)
Family:	Papillomaviridae
Genus:	Kappapapillomavirus
Species:	Cottontail rabbit papillomavirus

Rabbit with Shope papillomavirus infection.

Engraving from Tableau Encyclopedique et Methodique, 1789.‎

The cottontail rabbit papilloma virus (CRPV), or Shope papilloma virus, is a type I virus under the Baltimore scheme, possessing a nonsegmented dsDNA genome.^[1] It infects rabbits, causing keratinous carcinomas, typically on or near the animal’s head. These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation.

Shope papillomavirus provided the first mammalian model of a cancer caused by a virus. It takes its name from Dr. Richard E. Shope, who discovered it in the 1930s. Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors.^[2] The virus was sequenced in 1984, showing substantial sequence similarities to HPV1a.^[3] It has been used as a model for human papillomaviruses both before and after this discovery. The most visible example of this role is the HPV vaccine, which was developed based on and incorporating research done using the virus as a model. Similarly, it has been used to investigate antiviral therapies.^[4]

The virus is also a possible source of myths about the jackalope, a rabbit with the antlers of an antelope, and related cryptids such as the wolpertinger.^[5][6] Stories and illustrations of horned rabbits appear in scientific treatises dating back many years, such as the Tableau encyclopédique et méthodique, from 1789.^[7]

References

1. ^ "Cottontail rabbit papillomavirus" in UniProt
2. ^ http://www.ratsteachmicro.com/2003_HCOE_PDFs/Papovavirus_Lecture_Outline__2005rev.pdf
3. ^ Giri, Isabelle; Danos, Olivier; Yaniv, Moshe (1985), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus", PNAS 82 (6): 1580–1584, doi:10.1073/pnas.82.6.1580, http://www.pnas.org/cgi/reprint/82/6/1580.pdf 
4. ^ Christensen ND, ND (2005), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus", Antivir Chem Chemother 16 (6): 355–62, PMID 16331841 
5. ^ Eberhart, George M. "Mysterious Creatures: Creating A Cryptozoological Encyclopedia." 2005. Journal of Scientific Exploration. Vol. 19, No. 1, pp. 103-113
6. ^ Eberhart, George M. (2002), Mysterious Creatures: A Guide to Cryptozoology, 1, ABC-CLIO, pp. 237–238, ISBN 1576072835 
7. ^ "Cottontail rabbit papillomavirus was the first mammalian papillomavirus to be discovered"

This veterinary medicine–related article is a stub. You can help Wikipedia by expanding it.v · Categories: Rabbit diseases Viral diseases Rabbits and hares Animal virology Papillomavirus Veterinary medicine stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Anger, Bavaria Bayerisch Gmain Look at other dictionaries: Shope papilloma virus — Shope papilloma virus. См. вирус папилломы Шоупа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь. Shope papilloma virus — Papovavirus that produces papillomas (warts) in rabbits …   Dictionary of molecular biology Shope papilloma — shōp also Shope s papilloma shōps n a transmissible fibroma of cottontail rabbits that occurs esp. on the legs, feet, and ears, is caused by a poxvirus (species Rabbit fibroma virus of the genus Leporipoxvirus), and has under certain… …   Medical dictionary shope papilloma — ˈshōp noun also shope s papilloma Usage: usually capitalized S Etymology: after Richard E. Shope died 1966 American physician : a transmissible fibrous tumor of cottontail rabbits of which the transmitting agent is believed to be a specific… …   Useful english dictionary Virus — A microorganism smaller than a bacteria, which cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with… …   Medical dictionary Shope — Richard E., U.S. pathologist, 1902–1966. See S. fibroma, S. fibroma virus, S. papilloma, S. papilloma virus …   Medical dictionary Liste De Virus — Ceci est une liste de virus biologiques et de types de virus. Veuillez ajouter ou modifier cette liste si nécessaire. Certains de ces termes peuvent être des synonymes pour le même virus ; s il existe déjà un article sur ce virus sous un… …   Wikipédia en Français Liste de virus — Ceci est une liste de virus biologiques et de types de virus. Veuillez ajouter ou modifier cette liste si nécessaire. Certains de ces termes peuvent être des synonymes pour le même virus ; s il existe déjà un article sur ce virus sous un… …   Wikipédia en Français rabbit papilloma — Shope papilloma a viral disease of rabbits marked by the formation of horny warts. These papillomas were the first mammalian tumors shown to be induced by a virus (by Shope in 1933) and the first to be transmitted by purified viral DNA …   Medical dictionary Papilloma — A benign tumor that projects above the surface of the tissue from which it arises. Papillomas have clearcut borders and are usually small and fairly round. * * * A circumscribed, benign epithelial tumor projecting from the surrounding surface;… …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”