DiOC6

DiOC6
DiOC6[1]
IUPAC name
3-Hexyl-2-[3-(3-hexyl-2(3H)benzoxazolylidene)-1-propenyl]benzoxazolium iodide
Other names
3,3′-Dihexyloxacarbocyanine iodide
Identifiers
CAS number 53213-82-4
PubChem 9894321
Jmol-3D images Image 1
Properties
Molecular formula C29H37IN2O2
Molar mass 572.52 g mol−1
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

DiOC6 (3,3′-dihexyloxacarbocyanine iodide) is a fluorescent dye used for the staining of a cell's endoplasmic reticulum,[2] vesicle membranes and mitochondria.[3] Binding to these structures occurs via the dye's hydrophilic groups. DiOC6 can be used to label living cells, however they are quickly damaged due to photodynamic toxicity, so cells stained with this dye can only be exposed to light for short periods of time. When exposed to blue light, the dye fluoresces green.

References

  1. ^ 3,3′-Dihexyloxacarbocyanine iodide at Sigma-Aldrich
  2. ^ Terasaki M. (1989). "Fluorescent labeling of endoplasmic reticulum". Methods Cell Biol. 29: 125–35. PMID 2643757. 
  3. ^ Koning AJ et al. (1993). "DiOC6 staining reveals organelle structure and dynamics in living yeast cells". Cell Motil Cytoskeleton 25 (2): 111–28. doi:10.1002/cm.970250202. PMID 7686821. 


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