Keratinocyte Growth Factor

Keratinocyte Growth Factor

The Keratinocyte Growth Factor (KGF) is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.

KGF, also referred to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.

There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

External links

*http://www-personal.umich.edu/~lpt/fgf/1fq9_files/side.jpg
*http://www-personal.umich.edu/~lpt/fgf/1fq9.htm


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • keratinocyte growth factor — KGF. A natural substance that stimulates the growth of epithelial cells in the skin and in the lining of the mouth, stomach, and intestines. A form of KGF made in the laboratory is called recombinant human keratinocyte growth factor. Also called… …   English dictionary of cancer terms

  • keratinocyte growth factor — A growth factor structurally related to fibroblast growth factor …   Dictionary of molecular biology

  • Fibroblast growth factor — Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin binding proteins and interactions with cell surface associated heparan sulfate… …   Wikipedia

  • Fibroblast growth factor receptor 2 — PDB rendering based on 1djs …   Wikipedia

  • Fibroblast growth factor receptor 4 — Fibroblast growth factor receptor 4, also known as FGFR4, is a human gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334). PBB Summary section title = summary text = The protein encoded by this gene is a member of the… …   Wikipedia

  • Hepatocyte growth factor — Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on… …   Wikipedia

  • Transforming growth factor — (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGF beta;. The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not… …   Wikipedia

  • Heparin-binding EGF-like growth factor — PDB rendering based on 1xdt …   Wikipedia

  • Factor de crecimiento de fibroblastos — Un factor de crecimiento de fibroblastos (FGF, por fibroblast growth factor) es un factor de crecimiento que aumenta el índice de actividad mitótica y síntesis de ADN facilitando la proliferación de varias células precursoras, como el… …   Wikipedia Español

  • Keratinocyte transglutaminase — Transglutaminase 1 (K polypeptide epidermal type I, protein glutamine gamma glutamyltransferase), also known as TGM1, is a human gene.cite web | title = Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein glutamine gamma …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”