Lipoamide

Lipoamide

Chembox new
ImageFile = Lipoamide-2D-skeletal.png ImageSize =
IUPACName =
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Section1 = Chembox Identifiers
CASNo = 940-69-2
PubChem = 863
SMILES = NC(=O)CCCC [C@@H] 1CCSS1
MeSHName = lipoamide
Section2 = Chembox Properties
Formula = C8H15NOS2
MolarMass = 205.343 g/mol
Appearance =
Density =
MeltingPt =
BoilingPt =
Section3 = Chembox Hazards
Solubility =
MainHazards =
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Lipoamide is a trivial name for 6,8-dithiooctanoic amide. It is 6,8-dithiooctanoic acid's functional form where the carboxyl group is attached to protein (or any other amine) by an amide linkage (containing -NH2) to an amino group.

Lipoamide forms a thioester bond, oxidizing the disulfide bond, with acetaldehyde (pyruvate after it has been decarboxylated). It then transfer the acetaldehyde group to CoA which can then continue in the TCA cycle.

ee also

* Lipoic acid


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Look at other dictionaries:

  • Lipoamide — Général Nom IUPAC 5 (1,2 dithiolan 3 yl)pentanamide Synonymes ami …   Wikipédia en Français

  • lipoamide dehydrogenase — An enzyme that regenerates lipoamide from the reduced form dihydrolipoamide …   Dictionary of molecular biology

  • lipoamide — The functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group …   Dictionary of molecular biology

  • lipoamide — noun The compound 6,8 dithiooctanoic amide …   Wiktionary

  • lipoamide — See lipoic acid. * * * lipo·am·ide (lip″o amґīd) lipoic acid in amide linkage with lysine side chains of enzymes of the α ketoglutarate dehydrogenase, branched chain α keto acid dehydrogenase, and pyruvate dehydrogenase… …   Medical dictionary

  • lipoamide dehydrogenase — SYN: dihydrolipoamide dehydrogenase. * * * lipo·am·ide de·hy·dro·gen·ase (lip″o amґīd de hiґdro jən″ās) erroneous name for dihydrolipoyl dehydrogenase …   Medical dictionary

  • lipoamide disulfide — Oxidized lipoic acid in amide combination with the ε amino group of an l lysyl residue of pyruvic acid dehydrogenase …   Medical dictionary

  • lipoamide reductase — SYN: dihydrolipoamide dehydrogenase …   Medical dictionary

  • Pyruvate dehydrogenase (lipoamide) alpha 1 — PDB rendering based on 1ni4 …   Wikipedia

  • pyruvate — A salt or ester of pyruvic acid. active p. an intermediate formed in the oxidative decarboxylation of p.. Cf.:p. dehydrogenase (lipoamide). SYN: α lactyl thiamin pyrophosphate. p. carboxylase ligase …   Medical dictionary

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