Ganglioside GM2 activator protein
- Ganglioside GM2 activator protein
Ganglioside GM2 activator protein is (GM2-AP) is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation.
This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
It was identified as a member of ML domain family of proteins involved in innate immunity and lipid metabolism in SMART database. [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=ML&BLAST=DUMMY] .
External links
* [http://www.ebi.uniprot.org/entry/P17900 Uniprot entry]
* - Calculated orientations of Ganglioside GM2 activator proteins in membrane
ee also
*Gangliosidosis
*Sandhoff disease
*Tay-Sachs disease
*Hexosaminidase
*GM1
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