Ganglioside GM2 activator protein

Ganglioside GM2 activator protein

Ganglioside GM2 activator protein is (GM2-AP) is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation.

This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

It was identified as a member of ML domain family of proteins involved in innate immunity and lipid metabolism in SMART database. [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=ML&BLAST=DUMMY] .

External links

* [http://www.ebi.uniprot.org/entry/P17900 Uniprot entry]
* - Calculated orientations of Ganglioside GM2 activator proteins in membrane

ee also

*Gangliosidosis
*Sandhoff disease
*Tay-Sachs disease
*Hexosaminidase
*GM1


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