Trimethylsilyl azide

Trimethylsilyl azide

Trimethylsilyl azide ((CH3)3SiN3) is a chemical compound used as a reagent in organic chemistry. It can be produced from trimethylsilyl chloride and sodium azide [Organic Syntheses, Coll. Vol. 6, p.1030 (1988); Vol. 50, p.107 (1970). [http://www.orgsyn.org/orgsyn/prep.asp?prep=cv6p1030 Link] .] It is considered a safer replacement for hydrazoic acid in many reactions. It will however over time hydrolyze to hydrogen azide and therefore it must be stored free of moisture ["Trimethylsilyl Azide (TMSN3): A Versatile Reagent in Organic Synthesis" Mohammad Jafarzadeh SYNLETT 2007, No. 13, pp 2144–2145 DOI|10.1055/s-2007-984895 Open access] . For an example of its use: see Oseltamivir total synthesis.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Trimethylsilyl chloride — Trimethylsilyl chloride …   Wikipedia

  • Azide — The azide anion The azide functional group Azide is the anion with the formula N3−. It is the conjugate base of hydrazoic acid. N3− is a linear …   Wikipedia

  • Azoture de triméthylsilyle — Général Nom IUPAC Azido(triméthyl)silane No CAS …   Wikipédia en Français

  • Oseltamivir total synthesis — concerns the total synthesis of the antiinfluenza drug oseltamivir marketed by Hoffmann La Roche under the trade name Tamiflu. Its commercial production starts from the biomolecule shikimic acid harvested from Chinese star anise with a limited… …   Wikipedia

  • Chlorure de triméthylsilyle — Chlorure de triméthylsilyle …   Wikipédia en Français

  • Organosilicon — compounds are organic compounds containing carbon silicon bonds. Organosilicon chemistry is the corresponding science exploring their properties and reactivity.[1] Like carbon, the organically bound silicon is tetravalent and tetrahedral. Carbon… …   Wikipedia

  • Tetrasulfur tetranitride — Tetrasulfur tetranitride …   Wikipedia

  • Mukaiyama Taxol total synthesis — overview from raw material perspective The Mukaiyama taxol total synthesis published by the group of Teruaki Mukaiyama of the Tokyo University of Science between 1997 and 1999 was the 6th successful taxol total synthesis. The total synthesis of… …   Wikipedia

  • Common reagents — This is a list of common inorganic and organic reagents often used in chemistry. Contents 1 Synopsis 2 Reagent Compounds 3 See also 4 References S …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”