Paternal age effect

Paternal age effect

The paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do. This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime.

Disorders correlated with paternal age

Achondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; bipolar disorder; and 25% of schizophrenia cases are correlated with advanced paternal age.

Other disorders related to advanced paternal age are:
*Wilms' tumor
*Thanatophoric dysplasia
*Retinitis pigmentosa
*Osteogenesis imperfecta type IIA
*Acrodysostosis
*Fibrodysplasia ossificans progressiva
*Aniridia
* Bilateral retinoblastoma
* Multiple exostoses
*Marfan Syndrome
*Lesch-Nyhan syndrome
*Pfeiffer Syndrome
*Wardenburg Syndrome
*Treacher-Collins Syndrome
*Soto’s basal cell nevus
*Cleidocranial dysostosis
*Polyposis coli
*Oculodentodigital syndrome
*Costello syndrome
*Progeria
* Recklinghausen’s neurofibromatosis
*Tuberous sclerosis
*Polycystic kidney disease
*Hemophilia A
*Duchenne muscular dystrophy
*Athetoid Cerebral Palsy
*Dystonic Cerebral Palsy
*Congenital Hemiplegia
*Down syndrome
*Bipolar disorder

References

*cite journal | author = Crow JF | title = The high spontaneous mutation rate: Is it a health risk? | journal = PNAS | volume = 94 | url = http://www.pnas.org/cgi/content/full/94/16/8380 | pages = 8380–6 | year = 1997 | doi = 10.1073/pnas.94.16.8380
*cite journal | author = Bertram L, Busch R, Spiegl M, Lautenschlager NT, Müller U, Kurz A | title = Paternal age is a risk factor for Alzheimer disease in the absence of a major gene | journal = Neuroscience | volume = 1 | issue = 4 | url = http://www.springerlink.com/content/j2xvhj1r9c4vyh6h/ | pages = 277–80 | year = 1998 | doi = 10.1007/s100480050041
*cite journal | author = Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D | title = Paternal age and schizophrenia: a population based (sic) cohort study | journal = BMJ Online | url = http://www.bmj.com/cgi/content/abstract/bmj.38243.672396.55v1 | year = 2004 | pmid = 15501901
*cite web | title = DNA repair activity linked to paternal age effect | url = http://www.uthscsa.edu/opa/issues/new33-32/graduate.htm | publisher = University of Texas Health Science Center at San Antonio | date = 2000-08-28
*cite journal | author = Bray I, Gunnell D, Smith GD | title = Advanced paternal age: How old is too old? | journal = Journal of Epidemiology and Community Health | volume = 60 | url = http://jech.bmj.com/cgi/content/abstract/60/10/851 | pages = 851–3 | year = 2006 | doi = 10.1136/jech.2005.045179
*cite journal | author = Montgomery SM, Lambe M, Tomas O, Ekbom A | title = Paternal age, family size, and risk of multiple sclerosis | journal = Epidemiology | volume = 15 | issue = 6 | url = http://www.epidem.com/pt/re/epidemiology/abstract.00001648-200411000-00011.htm;jsessionid=FTyPmJX2pQ0vndYv7JDFBhGxjJJcM6NbJ7XTtxh2LWfyx6nMnGGv!-2083468996!-949856145!8091!-1 | pages = 717–23 | year = 2004 | doi = 10.1097/01.ede.0000142138.46167.69
*cite journal | author = Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, Rabinowitz J, Shulman C, Malaspina D, Lubin G, Knobler HY, Davidson M, Susser E | title = Advancing paternal age and autism | journal = Archives of General Psychiatry | volume = 63 | issue = 9 | url = http://archpsyc.ama-assn.org/cgi/content/abstract/63/9/1026 | pages = 1026–32 | year = 2006 | doi = 10.1001/archpsyc.63.9.1026
*cite web | author = Sanders L | title = College scientist named Ellison Senior Scholar | publisher = University of Southern California College of Letters, Arts & Sciences | url = http://www.usc.edu/schools/college/news/december_2005/arnheim.html | date = 2005
*cite journal | author = Fisch H, Hyun G, Golden R, Hensle TW, Olsson CA, Liberson GL | title = The influence of paternal age on down syndrome (sic) | journal = J Urol | volume = 169 | issue = 6 | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12771769&dopt=Abstract | pages = 2275–8 | year = 2003 | pmid = 12771769 | doi = 10.1097/01.ju.0000067958.36077.d8
*cite journal | author = Rami B, Schneider U, Imhof A, Waldhör T, Schober E | title = Risk factors for type I diabetes mellitus in children in Austria | journal = Eur J Pediatr | volume = 158 | issue = 5 | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10333115&query_hl=22&itool=pubmed_docsum | pages = 362–6 | year = 1999 | pmid = 10333115 | doi = 10.1007/s004310051092
*cite journal | author = Singh NP, Muller CH, Berger RE | title = Effects of age on DNA double-strand breaks and apoptosis in human sperm | journal = Fertility and sterility | volume = 80 | issue = 6 | url = http://cat.inist.fr/?aModele=afficheN&cpsidt=15380275 | pages = 1420–30 | year = 2003 | doi = 10.1016/j.fertnstert.2003.04.002
*cite journal | author = Lauritsen MB, Pedersen CB, Mortensen PB | title = Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study | journal = J Child Psychol Psychiatry | volume = 46 | issue = 9 | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16108999&query_hl=2&itool=pubmed_docsum | pages = 963–71 | year = 2005 | pmid = 16108999 | doi = 10.1111/j.1469-7610.2004.00391.x
*cite journal | author = Wohl M, Gorwood P | title = Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring | journal = Eur Psychiatry | volume = 22 | issue = 1 | url = http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17142012&query_hl=13&itool=pubmed_docsum | pages = 22–6 | year = 2007 | pmid = 17142012 | doi = 10.1016/j.eurpsy.2006.08.007
*cite web | title = Schizophrenia Research Forum: Current Hypotheses | url = http://www.schizophreniaforum.org/for/curr/Malaspina/default.asp | date = 2006-03-28
*cite journal | author = Choi J-Y, Lee K-M, Park SK, Noh D-Y, Ahn S-H, Yoo K-Y, Kang D | title = Association of paternal age at birth and the risk of breast cancer in offspring: a case control study | journal = BMC Cancer | volume = 5 | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291359 | pages = 143 | year = 2005 | doi = 10.1186/1471-2407-5-143
*cite web | title = NW Andrology & Cryobank | url = http://www.nwcryobank.com/donor_standards.html
*cite journal | author = Croen LA, Najjar DV, Fireman B, Grether JK | title = Maternal and paternal age and risk of autism spectrum disorders | journal = Archives of Pediatrics and Adolescent Medicine | volume = 161 | issue = 4 | url = http://archpedi.ama-assn.org/cgi/content/short/161/4/334 | pages = 334–40 | year = 2007 | doi = 10.1001/archpedi.161.4.334
*cite journal | author = Tarin JJ, Brines J, Cano A | title = Long-term effects of delayed parenthood | journal = Human Reproduction | volume = 13 | issue = 9 | url = http://humrep.oxfordjournals.org/cgi/reprint/13/9/2371 | pages = 2371–6 | year = 1998 | doi = 10.1093/humrep/13.9.2371

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Maternal age effect — The maternal age effect describes the exponentially increasing risks for numerical chromosomal abnormalities among a prospective mother s gametes as she ages. This increase reflects the overall increase in the rate of nondisjunction with maternal …   Wikipedia

  • Advanced maternal age — See also: Paternal age effect Advanced maternal age is defined as an increase in the age at which women give birth to their first child, is now a widespread, and indeed near universal, phenomenon across the OECD countries. In Western, Northern,… …   Wikipedia

  • Pregnancy over age 50 — has become more possible for women, due to recent advances in assisted reproductive technology, such as egg donation. Typically, a woman s fecundity ends with menopause, which by definition is 12 consecutive months without having had a period.… …   Wikipedia

  • Cinderella effect — This article is about parenting. For the effect with the same name in semiconductors, see floating body effect. The Cinderella effect is a term used by psychologists to describe the high incidence of stepchildren being physically abused,… …   Wikipedia

  • Dutch Golden Age painting — Dutch Masters redirects here. For the cigar, see Dutch Masters (cigar). Johannes Vermeer, The Milkmaid (1658–1660) Dutch Golden Age painting is the painting of the Dutch Golden Age, a period in Dutch history generally spanning the 17th century,[ …   Wikipedia

  • Sperm donation — is the provision (or ‘donation’) by a man, (known as a ‘sperm donor’), of his sperm, with the intention that it be used to impregnate a woman who is not usually the man s sexual partner, in order to produce a child. A sperm donor is the natural… …   Wikipedia

  • Menstrual cycle — See also: Menstruation and Menstruation (mammal) The menstrual cycle is the scientific term for the physiological changes that can occur in fertile women. This article focuses on the human menstrual cycle. The menstrual cycle, under the… …   Wikipedia

  • Синдром Дауна — Американский актёр Крис Бурк, живущий с синдромом Дауна …   Википедия

  • Болезнь Дауна — Синдром Дауна Ребёнок с синдромом Дауна МКБ 10 Q90. МКБ 9 …   Википедия

  • Дауна болезнь — Синдром Дауна Ребёнок с синдромом Дауна МКБ 10 Q90. МКБ 9 …   Википедия

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”