Maternal age effect

Maternal age effect

The maternal age effect describes the exponentially increasing risks for numerical chromosomal abnormalities among a prospective mother's gametes as she ages. This increase reflects the overall increase in the rate of nondisjunction with maternal age.Fact|date=March 2008

Paternal age does have an effect however. A research study conducted by Fisch et al. [ [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7XMT-4HG54PP-2G&_user=122868&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010083&_version=1&_urlVersion=0&_userid=122868&md5=a881792ba58c1e142dfa78fc4104dada The Influence of Paternal Age on Down Syndrome] ] showed that paternal age has a negligible effect up to the age of 35. Over the age of 35, a paternal effect is seen in conjunction with a maternal age of over 35 and was most pronounced when maternal age was 40 or over. In this group, the paternal age effect was 50%. This trend is common to all non-inherited familial causes of genetic disease. This is because a woman's ova only divide a total of 24 times throughout life, the first 23 of which happen in utero, whereas men's sperm divide continuously throughout life, leading to gradually increasing copy errors. Trisomy 21 derived from maternal age effect is due to an error when the egg splits.

ources

ee also

*Paternal age effect


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Paternal age effect — The paternal age effect describes the influence that a father s age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men… …   Wikipedia

  • Advanced maternal age — See also: Paternal age effect Advanced maternal age is defined as an increase in the age at which women give birth to their first child, is now a widespread, and indeed near universal, phenomenon across the OECD countries. In Western, Northern,… …   Wikipedia

  • Maternal oral health — has been shown to effect the well being of both the mother and her unborn fetus. Oral health has long been considered an arena of its own, distinct from general health, but there has been a recent push to bring together these two fields. The 2000 …   Wikipedia

  • Maternal deprivation — Mother and child The term maternal deprivation is a catch phrase summarising the early work of psychiatrist and psychoanalyst, John Bowlby on the effects of separating infants and young children from their mother (or mother substitute)[1]… …   Wikipedia

  • Cinderella effect — This article is about parenting. For the effect with the same name in semiconductors, see floating body effect. The Cinderella effect is a term used by psychologists to describe the high incidence of stepchildren being physically abused,… …   Wikipedia

  • Pregnancy over age 50 — has become more possible for women, due to recent advances in assisted reproductive technology, such as egg donation. Typically, a woman s fecundity ends with menopause, which by definition is 12 consecutive months without having had a period.… …   Wikipedia

  • Dragon Age: Origins — Developer(s) BioWare Edmonton Edge of Reality (console versions)[1] Publisher(s) …   Wikipedia

  • Down syndrome — Classification and external resources Boy with Down syndrome assembling a …   Wikipedia

  • List of effects — This is a list of names for observable phenonema that contain the word effect, amplified by reference(s) to their respective fields of study. #*3D audio effect (audio effects)A*Accelerator effect (economics) *Accordion effect (physics) (waves)… …   Wikipedia

  • Genetic origins of Down syndrome — Down syndrome is a chromosomal abnormality characterized by the presence of an extra copy of genetic material on the 21st chromosome, either in whole (trisomy 21) or part (such as due to translocations). The effects of the extra copy varies… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”