Large-conductance mechanosensitive channel
- Large-conductance mechanosensitive channel
Mechanosensitive ion channels (MscL) play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. [cite journal |author=Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC |title=Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel |journal=Science |volume=282 |issue=5397 |pages=2220–6 |year=1998 |pmid=9856938 |doi=10.1126/science.282.5397.2220]
MscL forms a channel organized as a homopentamer, with each subunit containing two transmembrane α-helices. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) that opens in response to stretch forces in the lipid bilayer and participate in the regulation of osmotic pressure within the cell. [cite journal |author=Moe PC, Blount P, Kung C |title=Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation |journal=Mol. Microbiol. |volume=28 |issue=3 |pages=583–92 |year=1998 |pmid=9632260 |doi=10.1046/j.1365-2958.1998.00821.x]
ee also
*Mechanosensitive ion channel
References
External links
* [http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF01741 MscL in Pfam]
*
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