- Mark Bender Gerstein
-
Gerstein, Mark Bender Residence US, UK Nationality US Fields Bioinformatics Institutions Yale, Stanford Alma mater Harvard, Cambridge Doctoral advisor Cyrus Chothia,[1] Ruth Lynden-Bell Notable awards W. M. Keck Foundation Distinguished Young Scholar, Herschel-Smith Scholarship Professor Mark B. Gerstein is an American scientist working in bioinformatics. As of 2009[update], he is co-director of the Yale Computational Biology and Bioinformatics program, and Albert L. Williams Professor of Biomedical Informatics, Professor of Molecular Biophysics & Biochemistry and Professor of Computer Science at Yale University.
Contents
Education
After graduating from Harvard College summa cum laude with an A.B. in Physics in 1989, Gerstein studied under Ruth Lynden-Bell in the chemistry department of Cambridge University and Cyrus Chothia of the British Medical Research Council, earning a doctorate in 1993 from the University of Cambridge. He then went on to postdoctoral research in bioinformatics at Stanford University from 1993-1996 under Michael Levitt.
Publications and editorial positions
Gerstein has a number of scientific publications [2][3][4][5][6] and non-scientific publications in more popular forums.[7] He serves on a number of editorial and advisory boards, including those of PLOS Computational Biology, Genome Research, GenomeBiology, and Molecular Systems Biology.
Awards and memberships
In addition to a W. M. Keck Foundation Distinguished Young Scholars award, Gerstein has received awards from the US Navy, IBM, Pharmaceutical Research and Manufacturers of America, and the Donaghue Foundation. He is a Fellow of the AAAS. Other awards include a Herchel-Smith Scholarship supporting his doctoral work at Emmanuel College and a Damon Runyon Cancer Research Foundation Postdoctoral Fellowship. He is a contributor to a number of scientific consortia including ENCODE, modENCODE and the 1000 Genomes Project.
Research
Gerstein does research in the field of bioinformatics. This involves applying a range of computational approaches to problems in molecular biology, including data mining and machine learning, molecular simulation, and database design. His research group has a number of foci including annotating the human genome, personal genomics, building tools in support of genome technologies (such as next-generation sequencing), analyzing molecular networks, and simulating macromolecular motions. Notable databases and tools that the group has developed include the Database of Macromolecular Motions, which categorizes macromolecular conformational change; tYNA,[8] which helps analyze molecular networks; PubNet,[9] which analyzes publication networks; PeakSeq,[10] which identifies regions in the genome bound by particular transcription factors; and PEMer,[11] which categorizes block variants in the genome. Gerstein has also written extensively on scientific communication and ways in which computational issues in molecular biology interface with broader aspects of computation in society.
Sources and notes
- ^ Gerstein, M.; Chothia, C. (1991). "Analysis of protein loop closure. Two types of hinges produce one motion in lactate dehydrogenase". Journal of molecular biology 220 (1): 133–149. doi:10.1016/0022-2836(91)90387-L. PMID 2067013.
- ^ List of Scientific Papers from the Gerstein Lab
- ^ Giaever, G.; Chu, A. M.; Ni, L.; Connelly, C.; Riles, L.; Véronneau, S.; Dow, S.; Lucau-Danila, A. et al. (2002). "Functional profiling of the Saccharomyces cerevisiae genome". Nature 418 (6896): 387–391. doi:10.1038/nature00935. PMID 12140549.
- ^ Zhu, H.; Bilgin, M.; Bangham, R.; Hall, D.; Casamayor, A.; Bertone, P.; Lan, N.; Jansen, R. et al. (2001). "Global Analysis of Protein Activities Using Proteome Chips". Science 293 (5537): 2101–2105. doi:10.1126/science.1062191. PMID 11474067.
- ^ Krogan, N. J.; Cagney, G.; Yu, H.; Zhong, G.; Guo, X.; Ignatchenko, A.; Li, J.; Pu, S. et al. (2006). "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae". Nature 440 (7084): 637–643. doi:10.1038/nature04670. PMID 16554755.
- ^ http://www.ncbi.nlm.nih.gov/pubmed?term=mark%20gerstein%5Bau%5D Mark Gerstein publications in PubMed
- ^ List of Non-technical Writing by Mark Gerstein
- ^ tYNA network analysis program
- ^ PubNet publication network analysis program
- ^ PeakSeq program for identifying binding sites in chipseq experiments
- ^ PEMer package for identifying structural variants in the genome
External links
- Gerstein Lab website
- Mark Gerstein's personal website
- Mark Bender Gerstein at the Mathematics Genealogy Project.
Categories:- American biologists
- American computer scientists
- Harvard University alumni
- Stanford University alumni
- Living people
- Yale University faculty
- Bioinformaticians
- Alumni of the University of Cambridge
Wikimedia Foundation. 2010.
