Rabeprazole

Rabeprazole

Drugbox
IUPAC_name = "2- [(4-(3-methoxypropoxy)- 3-methyl-pyridin-2-yl) methylsulfinyl] - 1H-benzoimidazole"




width2 = 240
CAS_number=117976-89-3
ATC_prefix=A02
ATC_suffix=BC04
PubChem=5029
DrugBank=APRD01212
C = 18 | H = 21 | N = 3 | O = 3 | S = 1
molecular_weight = 359.444 g/mol
smiles = COCCCOc1ccnc(CS(=O)c2nc3ccccc3 [nH] 2)c1C
bioavailability= 52%
metabolism = Hepatic
elimination_half-life= 1 - 1.5 hours
excretion = Renal
licence_US = Aciphex
pregnancy_US = B
legal_UK = POM
legal_US = Rx-only
routes_of_administration= Oral

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under the brand names Aciphex and Pariet.

Pharmacology

1D [http://www.sciencemag.org/cgi/content/abstract/321/5886/263] .

Indications and usage

  • gastric ulcer
  • peptic ulcer (PUD)
  • Maintenance of Healing of Erosive or Ulcerative GERD
  • Healing of Erosive and Ulcerative GERD
  • Healing of Duodenal Ulcers.
  • Treatment of Symptomatic GERD
  • Treatment of Pathological Hypersecretory conditions (Zollinger-Ellison)
  • Helicobactor Pylori Eradication to Reduce Risk of Duodenal Ulcer Recurrence

    Contraindications

  • hypersensitivity to Rabeprazole, substituted benzimidazoles or any of components of its pharmaceutical forms.
  • pregnancy
  • lactation

    Restriction of usage

  • acute hepatic failure
  • pediatric use in patients under 18 years of age (there are insufficient data about safety and efficiency of Rabeprazole in this group of patients)

    ide effects

    Rabeprazole Adverse reactions/Side effects includeFact|date=September 2008:

  • In clinical trials the most common side effect assessed as possibly or probably related to ACIPHEX was Headache in 2.4% of patients vs 1.6% taking placebo.
  • diarrhea
  • vomiting
  • nausea
  • abdominal pains
  • constipation
  • meteorism
  • dry mouth
  • increased or decreased appetite
  • asthenia
  • headache
  • sleeplessness
  • vertigo
  • thrombocytopenia
  • granulocytopenia
  • leukocytopenia
  • skin eruption
  • erythema
  • myalgia
  • arthralgia
  • muscle or bone pain

    Drug interactions

    Rabeprazole decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antiacids. Rabeprazole is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin).can be safe in pregnancy

    Overdosage

    There is no available data on symptoms of rabeprazole overdose.

    How supplied

    Rabeprazole as Aciphex,Rabeloc, Pariet is supplied in:

  • Tablet, Enteric-Coated; 10mg
  • Tablet, Enteric-Coated; 20mg

    FEM CARE PHARMA

    LAUNCHED

    DORAFEM TABLETS

    THAT COMBINES RABEPRAZOLE & DOMPERIDONE.

    References

    * Morii M, Takata H, Fujisaki H, Takeguchi N., The potency of substituted benzimidazoles such as E3810, omeprazole, Ro 18-5364 to inhibit gastric H+, K(+)-ATPase is correlatedwith the rate of acid-activation of the inhibitor, "Biochem. Pharmacol". 1990 Feb 15;39(4):661-7.
    * Prakash A, Faulds D., Rabeprazole, "Drugs". 1998 Feb;55(2):261-7; discussion 268.

    External links

    * [http://www.aciphex.com Official product site]
    * [http://www.medical-look.com/reviews/Aciphex.html Aciphex review]


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    • rabeprazole — noun /raˈbɛp.ɻə.zoʊl/ An antiulcer drug in the class of proton pump inhibitors …   Wiktionary

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    • AcipHex — Acip·Hex as ə .feks trademark used for a preparation of the sodium salt of rabeprazole * * * Ac·i·pHex (asґĭ feks″) trademark for a preparation of rabeprazole sodium …   Medical dictionary

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